| 欧 凯,杨 林.胃癌免疫治疗机制及临床应用的研究进展[J].中国肿瘤,2020,29(2):125-133. |
| 胃癌免疫治疗机制及临床应用的研究进展 |
| Research Advances in Mechanism and Clinical Application of Immunotherapy for Gastric Cancer |
| 中文关键词 修订日期：2019-06-16 |
| DOI：10.11735/j.issn.1004-0242.2020.02.A008 |
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| 中文关键词: 胃肿瘤 免疫治疗 免疫检查点 过继免疫疗法 癌症疫苗 |
| 英文关键词:gastric neoplasms immunotherapy immune checkpoint adoptive immunotherapy cancer vaccine |
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| 摘要点击次数: 2601 |
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| 中文摘要: |
| 摘 要：胃癌是发病率最高的癌症之一。现有的放化疗及手术治疗方法对于晚期胃癌患者的效果欠佳。免疫疗法方兴未艾，有望成为治疗晚期胃癌的有效方法。胃癌患者常处于免疫抑制状态，且分子类型多样。目前免疫疗法临床前和临床试验主要包括免疫检查点抑制剂、过继性细胞免疫疗法和癌症疫苗。提高已有免疫疗法的安全性和有效性，根据胃癌患者的个体特征匹配合适的免疫疗法，寻找新的免疫疗法可能是未来免疫疗法的主要发展方向。 |
| 英文摘要: |
| Abstract：Gastric cancer is one of the cancers with the highest incidence. The existing radiotherapy，chemotherapy and surgical therapy are not effective enough for patients with advanced gastric cancer. Immunotherapy has been rapidly developed and expected to be an effective method for treatment of advanced gastric cancer. Patients with gastric cancer are often in an immunosuppressive state with diverse molecular types. Currently，preclinical and clinical trials of immunotherapy mainly include immunological checkpoint inhibitors，adoptive cellular immunotherapy and cancer vaccines. The main development direction of immunotherapy in the future may be to improve the safety and effectiveness of the existing immunotherapy，according to the individual characteristics of gastric cancer patients to match appropriate immunotherapy and to search for new immunotherapy. |
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