| 贾思侬,谢 丽,李 磊.液体活检技术应用于肿瘤筛检的研究现状[J].中国肿瘤,2019,28(10):774-779. |
| 液体活检技术应用于肿瘤筛检的研究现状 |
| Liquid Biopsy in Early Screening of Cancer：Current Status and Perspectives |
| 投稿时间：2019-07-25 |
| DOI：10.11735/j.issn.1004-0242.2019.10.A010 |
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| 中文关键词: 液体活检 肿瘤 筛检 |
| 英文关键词:iquid biopsy tumor screening |
| 基金项目:上海市加强公共卫生体系建设三年行动计划重点学科项目（15GWZK0802）；上海市卫生和计划生育委员会卫生行业临床研究专项课题（20184Y0331） |
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| 中文摘要: |
| 摘 要：随着社会经济发展、城市化及人口老龄化进程加速、生活方式改变等，恶性肿瘤已成为严重威胁人们健康的重大慢性疾病，而高水准的肿瘤筛检技术可早期发现肿瘤的存在，通过肿瘤早诊早治，改善预后。液体活检技术是新兴的极具潜力的血液检测技术，凭借便捷、无创、经济等特点成为近年来关注的热点，其有望取代传统的肿瘤筛检技术，成为未来主流的筛检方式。全文将液体活检技术在肿瘤筛检中的应用现状进行汇总，并进一步检索在美国临床试验注册平台和中国临床试验注册中心注册的相关研究，深入探讨液体活检技术应用于肿瘤筛检的应用价值、可行性和未来发展方向。 |
| 英文摘要: |
| Abstract：With the rapid development of social economy，urbanization，population aging and the lifestyle changes，cancer has become a major chronic disease that seriously threatens people’s health. Cancer screening can detect the presence of tumor early，and cancer can be diagnosed and treated in time，the prognosis of patient can be improved. Liquid biopsy，an emerging technique with great potential，has become a focus of attention recently because of its convenience，non-invasiveness and less costs. It is expected to replace the traditional technique and become the mainstream cancer screening method in the future. In this article，the related studies in Clinicaltrials.gov registration platform and Chinese Clinical Trial Registry are searched，and the recent progress of liquid biopsy in cancer screening are summarized to focus on its application value，feasibility and future development direction. |
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