| 文进博,孙中明,缪丹丹.江苏省淮安市高危人群上消化道早期癌影响因素分析[J].中国肿瘤,2019,28(10):749-756. |
| 江苏省淮安市高危人群上消化道早期癌影响因素分析 |
| Influencing Factors about Early Cancer of Upper- Digestive Tract Among High-Risk Population in Huai’an City of Jiangsu Province |
| 投稿时间：2019-07-15 |
| DOI：10.11735/j.issn.1004-0242.2019.10.A006 |
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| 中文关键词: 早诊早治 影响因素 上消化道 早期癌 江苏 |
| 英文关键词:early detection and treatment influence factor upper gastrointestinal early cancer Jiangsu |
| 基金项目:2017年度省第五期“333工程”科研资助立项项目（BRA2017242）；淮安市应用研究与科技攻关（社会发展）项目（HAS201607?鄄2） |
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| 中文摘要: |
| 摘 要：［目的］ 分析2009—2017年淮安市淮河流域癌症早诊早治项目上消化道早期癌的影响因素。［方法］ 收集2009—2017年淮安市三个县（区）参加此项目的调查对象问卷内容及内镜检查信息。采用多因素Logistic回归分析调查问卷相关因素与上消化道早期癌之间的关系。［结果］最终纳入研究对象3961人，其中病例组351人，对照组3610人；男性1567人（39.6%）。单因素分析结果表明两组性别、吸烟、饮酒、教育、家庭人口数、家庭年收入、肿瘤家族史、饮水主要来源、新鲜水果、干果干菜、腌晒食品、烫热食品构成比存在统计学差异，P值均<0.05。多因素Logistic回归分析结果表明，女性人群，食用腌晒食品和烫热食品频次低的人群，患病风险显著降低，OR（95%CI）分别为0.41（0.30~0.57），0.55（0.41~0.74）和0.53（0.37~0.75）；有肿瘤家族史、饮水主要来源为浅井水或湖河水，以及食用新鲜水果频次低的人群患病风险显著增加，OR（95%CI）分别为1.96（1.53~2.51），2.24（1.05~4.78），1.53（1.18~1.98）。［结论］男性人群、有肿瘤家族史人群、饮水主要来源为浅井水或湖河水人群、食用腌晒食品和烫热食品频率高的人群、食用新鲜水果频次低的人群，患上消化道早期癌风险较高。应对有上述特征人群进行健康教育，改善饮食结构和生活方式。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the influnce factors about early cancer of upper-digestive tract in Huai’an city of Jiangsu province. ［Methods］ The questionnaires and endoscopic results were collected among residents from 3 counties of Huai’an City who participated in a cancer early detection and early treatment program of Huaihe river basin from 2009 to 2017. Multivariate Logistic regression was used to analyze the risk factors of cancers of upper-digestive tract. ［Results］ The data of 3961 participants(1567 males and 2394 females) were finally analyzed in the study，including 351 cancer patients(case group) and 3610 normal subjects(control group). The univariate analysis indicated that the gender，smoking，drinking，education，number of family members，family annual income，family history of cancer，main sources of drinking water，eating fresh fruits，eating dried fruits and vegetables，eating pickled and dried food，and eating hot food were significantly different between case group and control group(all P<0.05). The multivariate Logistic regression indicated that female sex(OR=0.41，95%CI：0.30~0.57)，low frequency of eating pickled，dried food(OR=0.55，95%CI：0.41~0.74) and hot food(OR=0.53，95%CI：0.37~0.75) had lower risk for cancers of upper-digestive tract. Subjects with a family history of cancer，with shallow well water or lake and river water as main sources of drinking water，as well as with low frequency of eating fresh fruit had a higher risk for cancers of upper-digestive tract with OR(95%CI) 1.96(1.53~2.51)，2.24(1.05~4.78) and 1.53(1.18~1.98)，respectively. ［Conclusion］The health education should be given to residents with high risk of upper-digestive tract cancers to improve their dietary habits and lifestyle. |
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