| 王泽凡,兰霞斌,温庆良.Research Progress on CAR-T Therapy in Treatment of Solid Tumors[J].中国肿瘤,2019,28(9):699-704. |
| Research Progress on CAR-T Therapy in Treatment of Solid Tumors |
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| 投稿时间：2019-03-27 |
| DOI：10.11735/j.issn.1004-0242.2019.09.A011 |
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| 中文关键词: 嵌合抗原受体 嵌合抗原受体T细胞（CAR-T） 免疫治疗 实体瘤 |
| 英文关键词:chimeric antigen receptor chimeric antigen receptor T-cell(CAR-T) immunotherapy solid tumors |
| 基金项目:国家自然科学基金（81672642） |
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| 中文摘要: |
| 摘 要：嵌合抗原受体T细胞（chimeric antigen receptor T-cell，CAR-T）应用于急性B淋巴细胞白血病治疗中取得的成功，证实了CAR-T疗法的临床价值。这也激发了许多研究者对CAR-T技术在实体瘤中运用的研究兴趣，多项CAR-T细胞治疗实体瘤的基础和早期临床试验正在开展。然而实体瘤和血液肿瘤在性质上的差异决定了CAR-T必须克服实体瘤微环境、靶点缺乏、归巢和活化维持等难关才能获得更好的预后。该文将从CAR-T治疗实体瘤的现状、存在的问题及解决方案等方面介绍CAR-T细胞治疗实体瘤的研究进展。 |
| 英文摘要: |
| Abstract：The success of chimeric antigen receptor T-cell(CAR-T) in the treatment of acute B lymphocytic leukemia confirms the clinical value of CAR-T immunotherapy. This has also stimulated many researchers’ interest in the application of CAR-T in treatment of solid tumors. Many pre-clinical and clinical trials of CAR-T therapy for solid tumors are underway. However，the difference in properties between solid tumors and hematological tumors determines that CAR-T therapy must be optimized to overcome some unique obstacles，such as tumor microenvironment，lack of tumor-specific targets，difficulty of homing，and maintenance of activity. This article reviews the research progress，problems，and solutions of CAR-T treatment for solid tumors. |
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