| 苏国栋,韩 宇,白玉贤.胃及胃食管结合部癌免疫治疗的研究进展[J].中国肿瘤,2019,28(8):615-620. |
| 胃及胃食管结合部癌免疫治疗的研究进展 |
| Progress in Immunotherapy for Gastric and Gastroesophageal Junction Cancer |
| 投稿时间：2019-04-17 |
| DOI：10.11735/j.issn.1004-0242.2019.08.A010 |
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| 中文关键词: 胃肿瘤 胃食管结合部癌 免疫治疗 免疫检查点抑制剂 过继性细胞治疗 联合治疗 |
| 英文关键词:gastric neoplasms gastroesophageal junction(GEJ) cancer immunotherapy immune checkpoint inhibitor adoptive cell therapy combination therapy |
| 基金项目: |
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| 摘要点击次数: 1784 |
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| 中文摘要: |
| 摘 要：免疫系统在调节肿瘤生长过程中起重要作用，它能够识别和清除新出现的“非己”成分，包括肿瘤细胞，发生基因突变的肿瘤细胞能否形成肿瘤取决于肿瘤细胞与免疫系统之间相互作用的结果。肿瘤免疫治疗是一种通过激活人体自身免疫系统来提高组织适应性免疫反应的特异性和长期记忆，以实现持久的肿瘤消退和可能的治愈手段。目前在消化道肿瘤中，大量的临床试验初步成果证实免疫治疗对于胃及胃食管结合部癌有效，本文将其免疫治疗的方法及最新临床进展作一综述。 |
| 英文摘要: |
| Abstract：The immune system which can identify and remove emerging non-self components，including tumor cells，plays an important role in regulating tumor growth. The ability of genetically mutated cells to form tumors depends on the interaction between tumor cells and the immune system. Tumor immunotherapy is a therapy of improving the specificity and long-term memory of tissue-adapted immune response by activating the autoimmune system to achieve lasting tumor regression and possible healing treatments. The preliminary results of clinical trials have confirmed the efficacy of immunotherapy for gastric and gastroesophageal junction cancer at present，and the methods and the latest clinical progress of the immunotherapy are reviewed in this article. |
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