| 于 佩,梁 赫,易宗毕.影响中国华北地区女性乳腺癌无病生存期的临床病理因素——多中心回顾性研究[J].中国肿瘤,2019,28(4):315-320. |
| 影响中国华北地区女性乳腺癌无病生存期的临床病理因素——多中心回顾性研究 |
| Clinicopathological Features Influencing the Disease-free Survival of Breast Cancer：A Multicenter Retrospective Study in North China |
| 投稿时间：2018-12-11 |
| DOI：10.11735/j.issn.1004-0242.2019.04.A012 |
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| 中文关键词: 乳腺肿瘤 复发转移 回顾性研究 |
| 英文关键词:breast neoplasms recurrence and metastatic retrospective study |
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| 中文摘要: |
| 摘 要：［目的］ 探讨华北地区乳腺癌术后复发不同时间间隔与临床病理特征的相关性。［方法］ 对华北地区3家医院2012年1月1日至2014年12月31日收治的术后复发转移的乳腺癌病例资料进行分析，分析影响近期复发和远期复发患者的临床病理特征、复发转移规律和特点。［结果］ 696例乳腺癌术后复发患者纳入研究，平均年龄为45.28岁，其中394例患者3年内发生复发转移（56.6%），3年以上复发转移患者共302例（43.4%）。本研究发现近期复发患者（DFS<36个月）具有初诊年龄低、淋巴结转移≥4个、肿瘤直径>2cm、雌孕激素受体阴性、HER-2阳性、辅助化疗和辅助内分泌治疗的特点；多因素分析显示，淋巴结转移数、术后辅助化疗及内分泌治疗是复发转移间隔时间的独立影响因素。［结论］ 淋巴结转移数≥4个、雌激素、孕激素受体阴性、HER-2表达阳性、术后未进行辅助化疗、内分泌治疗是乳腺癌术后发生早期复发的危险因素，应进行密切随访。 |
| 英文摘要: |
| Abstract：［Purpose］ To evaluate the relationship between clinicopathological features and disease-free survival (DFS) after surgery of breast cancer patients in North China.［Methods］ The data were collected from the database of female advanced breast cancer at 3 tertiary hospitals from various geographic areas in North China from 2012 to 2014. Chi-square tests were used to compare clinicopathological characteristics and treatments among breast cancer patients with early and late recurrence. The risk factors for the interval of recurrence were estimated by univariate and multivariate analyses. ［Results］ A total of 695 female breast cancer patients identified as eligible recurrent patients after surgery were included in the final analysis. Among them，394 cases had early recurrence(DFS<3 years) and 302 cases had late recurrence(DFS≥3 years). The recurrence and metastasis interval were significantly associated with the age at initial diagnosis，histological types，tumor size，nodal status，ER，PR，HER-2 expression，with chemotherapy and hormone therapy. Multivariate analysis showed that lymph node metastases，with chemotherapy and hormone therapy were the independent prognostic factors affecting the intervals of recurrence. ［Conclusion］ Lymph node metastases ≥4，ER negative，PR negative，HER-2 positive，hormone therapy are associated with shorter interval of recurrence and metastasis in breast cancer patients after surgery in North China. |
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