| 中文关键词: 长链非编码RNA 肿瘤代谢 糖代谢 脂代谢 谷氨酰胺代谢 能量代谢 |
| 英文关键词:long non-coding RNA tumor metabolism glucose metabolism lipid metabolism glutamine metabolism energy metabolism |
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| 中文摘要: |
| 摘 要：长链非编码RNA（long non-coding RNA，lncRNA）是一类长度大于200个核苷酸，不能编码蛋白质的调节性RNA分子，在肿瘤发生和发展中起关键作用。与正常细胞相比，肿瘤细胞表现出不同的代谢特征。LncRNA与肿瘤代谢有关。本文对lncRNA与肿瘤细胞代谢，特别是葡萄糖、谷氨酰胺和脂质代谢的最新进展作简要综述，以期通过更深入地了解lncRNA与肿瘤代谢的关系，为更好地开发靶向肿瘤代谢的新药奠定基础。 |
| 英文摘要: |
| Abstract：Long non-coding RNA (lncRNA) is defined as a large class of non- protein-coding，regulatory RNAs with molecules longer than 200 nucleotides，which play key roles in tumorigenesis and progression. Compared to normal cells，tumor cells exhibit distinct metabolic features，and lncRNAs are involved in tumor metabolism. This article reviews the recent advances in the relationship between lncRNA and tumor metabolism，particularly glucose，glutamine and lipid metabolism；and its application in the development of new drugs targeting tumor metabolism. |
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