| 雷 林,周海滨,尚庆刚.2001~2015年深圳市儿童肿瘤的发病特征和时间趋势[J].中国肿瘤,2019,28(4):281-285. |
| 2001~2015年深圳市儿童肿瘤的发病特征和时间趋势 |
| Incidence and Trends of Childhood Cancer in Shenzhen，2001~2015 |
| 投稿时间：2019-01-24 |
| DOI：10.11735/j.issn.1004-0242.2019.04.A007 |
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| 中文关键词: 儿童肿瘤 发病率 时间趋势 流行病学 深圳 |
| 英文关键词:childhood cancer incidence time trend epidemiology Shenzhen |
| 基金项目:深圳市医疗三名工程（SZSM201811057） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨2001~2015年深圳市儿童恶性肿瘤的流行特征和发病趋势，为制定深圳市儿童恶性肿瘤防治政策提供基础数据。［方法］ 根据深圳市肿瘤发病登记处收集的2001~2015年儿童恶性肿瘤发病数据和相应年份的人口资料，计算儿童恶性肿瘤发病粗率，以及标准化人口年龄调整的发病率（中国人口标化率和世界人口标化率），利用Joinpoint软件进行趋势分析。［结果］ 2001~2015年深圳市肿瘤登记处共登记儿童恶性肿瘤1068例，粗发病率为15.96/10万，中标率为15.42/10万，世标率为16.10/10万。男童发病率明显高于女童，男女发病性别比为1.25∶1。发病率前3位依次为白血病（7.07/10万）、脑/神经系统肿瘤（2.43/10万）和恶性淋巴瘤（1.21/10万）。从时间趋势上看，儿童恶性肿瘤发病率无明显变化，世标率APC为2.00%（Z=1.9，P=0.1），仅男童恶性肿瘤发病率略微上升，APC为3.38%（Z=2.7，P<0.01）；不同肿瘤（白血病、脑/神经系统肿瘤和恶性淋巴瘤）发病率也无明显改变。［结论］ 深圳市儿童恶性肿瘤发病率处于较高水平，需采取综合措施进行预防和控制。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the incidence and epidemiologic trends of childhood cancer in Shenzhen during 2001 to 2015.［Methods］ The childhood cancer incidence data and population data were collected from Shenzhen Cancer Registry. The crude incidence，age-standardized incidence by Chinese standard population(ASR China) and age-standardized incidence by world standard population(ASR world) were calculated. The annual percentage change(APC) of the incidence was analyzed by Joinpoint regression. ［Results］ Total 1068 new cases of childhood cancer were registered in Shenzhen Cancer Registry from 2001 to 2015. The crude incidence was 15.96/105，with ASR China of 15.59/105 and ASR world of 16.10/105. The incidence of boys was higher than that of girls，with a sex ratio of 1.25∶1. The top three cancer types were leukemia (7.07/105)，central nervous system tumors (2.43/105) and lymphomas (1.21/105). In terms of time trend，the incidence of childhood cancer had no significant increase of APC (APC=2.00%，Z=1.9，P=0.1)，but incidence of the boys had been increasing slightly (APC=3.38%，Z=2.7，P<0.01). The incidence of leukemia，central nervous system tumors and lymphomas were stable during 2001 to 2015. ［Conclusion］ The incidence of childhood is relatively high in Shenzhen，but the time trends are relatively stable during 2001 to 2015. |
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