| 李凯咪,邓 炯.乙醛脱氢酶2型与乙醛在肿瘤发生发展中的作用[J].中国肿瘤,2019,28(1):39-45. |
| 乙醛脱氢酶2型与乙醛在肿瘤发生发展中的作用 |
| Roles of Aldehyde Dehydrogenase 2 and Acetaldehyde in Tumor Initiation and Progression |
| 投稿时间：2018-10-12 |
| DOI：10.11735/j.issn.1004-0242.2019.01.A005 |
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| 中文关键词: 乙醛脱氢酶2型 乙醛 肿瘤 |
| 英文关键词:aldehyde dehydrogenase 2 acetaldehyde tumor |
| 基金项目:国家自然科学基金/国际合作重大项目（81620108022） |
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| 摘要点击次数: 1978 |
| 全文下载次数: 567 |
| 中文摘要: |
| 摘 要：乙醛脱氢酶2型(aldehyde dehydrogenase 2 family，ALDH2)是一种线粒体酶，其主要作用是将乙醛(acetaldehyde，ACE)代谢成乙酸，以供后续参与生物体的能量代谢与生物合成。在人群中，ALDH2活性位点存在高频率变异，致使该人群对酒精不耐受，易患急性酒精中毒等饮酒相关疾病。越来越多的证据显示，ALDH2基因的多样性在肿瘤的发生、生长、转移和抗药性中也发挥着重要作用。文章回顾了ALDH2以及其底物ACE在肿瘤研究中的最新进展，阐述了可调控其活性的药物及调控机制，并预测ALDH2可能成为癌症预后的标志物和癌症治疗的新靶点。 |
| 英文摘要: |
| Abstract：Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme，which catalyzes the oxidation of acetaldehyde to acetic acid for subsequent energy metabolism and biosynthesis. In human，there is a high frequency mutation in the ALDH2 active site，which confers a subpopulation intolerant to alcohol and susceptible to alcohol-related diseases，such as acute alcoholism. Emerging studies suggest that the genetic polymorphism of ALDH2 also plays an important role in tumorigenesis，tumor growth，metastasis，and drug resistance. In this review，the recent advances in cancer research of ALDH2 and acetaldehyde as well as the activity of regulatory drugs and its mechanisms are summerized. It is expected that ALDH2 may be used as a biomarker for cancer prognosis and a new target for cancer therapy. |
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