| 余艳琴,贾萌萌,郝金奇.中国女性三阴性乳腺癌发病相关因素的Meta分析[J].中国肿瘤,2018,27(11):881-888. |
| 中国女性三阴性乳腺癌发病相关因素的Meta分析 |
| Related Factors of Triple-negative Breast Cancer in Chinese Women：A Meta-analysis |
| 投稿时间：2018-05-19 |
| DOI：10.11735/j.issn.1004-0242.2018.11.A012 |
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| 中文关键词: 三阴性乳腺癌 危险因素 病例对照研究 Meta 分析 |
| 英文关键词:triple-negative breast cancer risk factor case-control study Meta-analysis |
| 基金项目:中国医学科学院医学与健康科技创新工程服务“一带一路”战略先导科研专项（2017-12M-B&R-03)；中国医学科学院肿瘤医院全国多中心晚期乳腺癌临床流行病学调查研究（CH-BC-045） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨中国女性三阴性乳腺癌发病相关的危险因素和保护因素。［方法］ 检索Pubmed、Medline、Embase、Cochrane Library、CNKI、VIP和万方数据库收录的所有关于中国女性三阴性乳腺癌发病相关因素的病例对照研究，病例组要求是三阴性乳腺癌，对照组是非三阴性乳腺癌患者。发表时间截止至2017年5月1日。由2位研究者独立筛选文献、提取资料和评价纳入研究的质量，采用Stata 12.0软件进行Meta分析。［结果］ 20个病例对照研究入选，研究总病例数37 273例；病例组6732例，对照组30541例。Meta分析结果显示，初潮年龄、生产次数、体质指数（BMI）、吸烟、流产次数、饮酒、居住地区、生育年龄与三阴性乳腺癌发病无相关性；与非三阴性乳腺癌相比，发病年龄60岁以上者、绝经、肿瘤家族史、不哺乳、服用避孕药、无生育史是三阴性乳腺癌发病的高危因素。亚组分析结果显示：北方地区初潮年龄大于13岁是保护因素，家族史和年龄超过60岁是危险因素。南方地区结果显示不哺乳、家族史、服用避孕药为危险因素。［结论］ 与非三阴性乳腺癌相比，绝经、肿瘤家族史、不哺乳、服用避孕药、无生育史、发病年龄60岁以上者是三阴性乳腺癌发病的危险因素，但受纳入研究的数量和质量的限制，上述结论尚需要进行前瞻性研究予以证实。 |
| 英文摘要: |
| Abstract：［Purpose］ To examine the risk and protective factors associated with triple-negative breast cancer in Chinese women. ［Methods］ Case-control studies about factors associated with the triple-negative breast cancer in Chinese women were searched in databases Pubmed，Medline，Embase，Cochrane Library，CNKI，VIP and Wanfang database up to May 1，2017. The case group in these studies was triple-negative breast cancer and the control group was non triple-negative breast cancer patients. Two researchers independently screened literatures，extracted data and evaluated the quality of the included studies. Meta analysis was conducted using Stata 12.0 software. ［Results］ A total of 20 studies involving 37 273 patients were included in the meta-analysis，including 6732 cases of triple-negative breast cancer and 30 541 cases of non triple-negative breast cancer. The meta-analysis showed that the age of menarche，times of birth，body mass index (BMI)，smoking，abortion，drinking，living area and child-bearing age were not associated with the triple-negative breast cancer，but the age of onset over 60 years，menopause，family history of cancer，non lactation，contraceptive use and no birth history were high risk factors for triple-negative breast cancer. Subgroup analysis showed the menarche age ≥13 years was protective factor，the family history and age over 60 years were risk factors in northern China；while no breast feeding，family history and contraceptive use were risk factors in southern China. ［Conclusion］ The triple-negative breast cancer in Chinese women is associated with menopause，cancer family history，non breast feeding，contraceptives，no birth history，and age of onset over 60 years. Due to the quantity and quality limitations of the study，it is needed for further studies to confirm the above findings. |
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