| 卢玉强,胡 婷,林初阳.广东省四会市鼻咽癌筛查方案应用的长期效果评价[J].中国肿瘤,2018,27(11):842-846. |
| 广东省四会市鼻咽癌筛查方案应用的长期效果评价 |
| Evaluation of Nasopharyngeal Carcinoma Screening Scheme in Sihui City，Guangdong Province |
| 投稿时间：2018-07-16 |
| DOI：10.11735/j.issn.1004-0242.2018.11.A005 |
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| 中文关键词: 鼻咽癌 筛查 生存率 广东 |
| 英文关键词:nasopharyngeal carcinoma screening survival rate Guangdong |
| 基金项目:中山大学临床医学研究5010计划项目(2013012) |
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| 中文摘要: |
| 摘 要：［目的］ 评价以VCA-IgA联合EBNA1-IgA为筛查指标开展鼻咽癌筛查，能否有效提高筛查检出患者的生存率。［方法］ 2008～2015年期间，在广东省四会市7个镇中招募30～69岁的当地居民参加鼻咽癌筛查，收集筛查人群与非筛查人群的鼻咽癌发病信息，用卡方检验比较筛查组与非筛查组的基本信息差异，通过Kaplan-Meier 法和Cox比例风险模型比较筛查组与非筛查组鼻咽癌患者的长期生存情况。 ［结果］ 无论在筛查组还是非筛查组中，男性鼻咽癌发病率均高于女性。筛查组鼻咽癌早诊率为53.57%（30/56），显著高于非筛查组（17.40%，43/247）(P<0.001)。Kaplan-Meier 法及Log-rank检验显示筛查组检出患者5年生存率为74.36%，非筛查组鼻咽癌患者5年生存率为63.90%，差异有统计学意义（P=0.044）。 ［结论］ 以VCA-IgA联合EBNA1-IgA为筛查指标的鼻咽癌筛查方案可提高鼻咽癌患者长期生存状况。该筛查方案值得在鼻咽癌高发区推广。 |
| 英文摘要: |
| Abstract：［Purpose］ To evaluate the nasopharyngeal carcinoma(NPC) screening scheme in Sihui city of Guangdong province. ［Methods］ Total 22 338 eligible residents aged 30 to 69 years old in 7 towns of Sihui city，Guangdong province were screened for NPC with VCA-IgA and EBNA1-IgA detection from 2008 to 2015(screening group)，and 96 955 non-screened residents served as controls. NPC patients were identified by regular check-up and the cancer registration. The basic information between screening and non-screening groups was compared by Chi-test. Kaplan-Meier methods，Log-rank test and Cox proportion hazard regression were conducted to compare the survival between two groups. ［Results］ The NPC incidence among males was higher than female both in screening or non-screening groups. The detection rate of early NPC in screening group was 53.57%(30/56），which was significantly higher than that in non-screening group(17.40%，43/247，P<0.001). Kaplan-Meier methods and Log-rank test showed that the overall 5-year survival rate of NPC patients in screening group(74.36%) was significantly higher than that in non-screening group(63.90%，P=0.044). ［Conclusion］ The NPC screening scheme with VCA-IgA and EBNA1-IgA detection can effectively increase the survival rate of NPC，which is worthy to be used in NPC high prevalent areas. |
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