| 颜美莹,张清媛.体质指数对乳腺癌患者辅助内分泌治疗预后的影响[J].中国肿瘤,2018,27(9):721-725. |
| 体质指数对乳腺癌患者辅助内分泌治疗预后的影响 |
| Effect of Body Mass Index on Prognosis of Patients with Breast Cancer Treated with Adjuvant Endocrine Therapy |
| 投稿时间：2018-01-31 |
| DOI：10.11735/j.issn.1004-0242.2018.09.A015 |
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| 中文关键词: 乳腺癌 体质指数 预后 内分泌治疗 |
| 英文关键词:breast cancer body mass index (BMI) prognosis endocrine therapy |
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| 中文摘要: |
| 摘 要：［目的］ 探讨体质指数(BMI)对乳腺癌患者辅助内分泌治疗预后的影响。［方法］ 对653例乳腺癌患者进行回顾性分析，利用ROC曲线下面积方法计算出BMI的界点，并对患者进行分组，评估BMI对无病生存期(disease-free survival，DFS)及总生存(overall survival，OS)的影响。生存分析采用Kaplan-Meier法和Log-rank检验，单因素和多因素分析采用Cox比例风险模型。［结果］ 653例乳腺癌患者均为女性，其中BMI＜25.7kg/m2组患者458例(70.1%)，BMI≥25.7kg/m2组195例(29.9%)。与BMI＜25.7kg/m2组患者比较，BMI≥25.7kg/m2组患者年龄较大(?字2=20.423，P＜0.001)，绝经后患者所占比例多(?字2=22.261，P＜0.001)。BMI＜25.7kg/m2组患者的DFS显著地长于BMI≥25.7kg/m2组(P＜0.001)。然而，两组之间的OS差异无统计学意义(P= 0.266)。多因素分析显示，年龄、肿瘤大小、淋巴结转移、Ki-67水平、p53表达和BMI均为影响乳腺癌患者DFS的独立不良因素。［结论］超重与肥胖是影响乳腺癌患者辅助内分泌治疗预后的不良因素。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the effect of body mass index (BMI) on prognosis of patients with breast cancer treated with adjuvant endocrine therapy. ［Methods］ A retrospective study of 653 breast cancer patients was carried out，and receiver operating characteristic(ROC) analysis was performed to calculate the cut-off of BMI. The effect of BMI on disease-free survival(DFS) and overall survival(OS) in these patients were evaluated. Kaplan-Meier analysis and Log-rank test were applied to perform survival analysis. The impact of different variables on survival was assessed by Cox populational-hazards regression model. ［Results］ A total of 653 female breast cancer patients were eligible，and 458 of patients were in the BMI ＜25.7kg/m2 group (70.1%)，and 195 of patients were in the BMI ≥25.7kg/m2 group(29.9%). Compared with patients in the BMI＜25.7kg/m2 group，the BMI≥25.7kg/m2 group had a higher rate of older age(X2=20.423，P＜0.001) and postmenopausal status(X2=22.261，P＜0.001). Patients in the BMI ＜25.7kg/m2 group had a longer DFS than patients in the BMI ≥25.7kg/m2 group (P＜0.001). However，there was no significant difference in OS between two groups (P=0.266). Multivariate analysis showed that age，tumor size，lymphatic metastasis，p53 and Ki-67 expression and BMI were independent prognostic factors for DFS of breast cancer patients. ［Conclusion］ Our findings suggest that high BMI is associated with a poor outcome in breast cancer patients treated with adjuvant endocrine therapy. |
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