| 孙 楠,李 源,孙守国.血液中炎症和脂质相关检测指标对非小细胞肺癌诊断价值的研究[J].中国肿瘤,2018,27(6):465-469. |
| 血液中炎症和脂质相关检测指标对非小细胞肺癌诊断价值的研究 |
| The Value of Blood Inflammation and Lipid-related Detection in Diagnosis of Non-small Cell Lung Cancer |
| 投稿时间：2018-04-12 |
| DOI：10.11735/j.issn.1004-0242.2018.06.A012 |
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| 中文关键词: 非小细胞肺癌 炎症 脂质 诊断 |
| 英文关键词:non-small cell lung cancer inflammation lipid diagnosis |
| 基金项目:中国医学科学院医学与健康科技创新工程（2016-I2M-1-001） |
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| 中文摘要: |
| 摘 要：［目的］ 研究血液中炎症因子和脂质分子对非小细胞肺癌（NSCLC）诊断的价值。［方法］ 将965例NSCLC患者和464名健康对照随机分成训练集和验证集两组，检测现有肿瘤标志物CEA、NSE、SCC及血小板（PLT）、中性粒细胞与单核细胞比例（NMR）、血红蛋白（HGB）、白蛋白（ALB）、高密度脂蛋白胆固醇（HDL）和甘油三酯（TG）等炎症因子和脂质分子。使用受试者工作曲线（ROC）分析单个分子的诊断效果，并使用逻辑二项回归方程在训练集中建立指标组合诊断模型，并在验证集中验证模型效果。［结果］ 与健康对照组相比，NSCLC患者的PLT、NMR和TG水平明显升高，HGB、ALB和HDL水平显著降低（P<0.001）。联合ALB、NMR、TG、NSE和SCC建立的模型对于NSCLC的诊断更有效：在训练集和验证集中的曲线下面积（AUC）分别为0.910和0.887，灵敏度分别为83.44%和76.76%，特异性为88.26%和86.23%。［结论］ PLT、NMR、HGB、ALB、HDL和TG在非小细胞肺癌患者与健康对照组间的水平有明显差异，其中ALB、NMR、TG、NSE和SCC联合使用可提高现有肿瘤标志物的诊断效率。 |
| 英文摘要: |
| Abstract：［Purpose］ To evaluate the value of blood inflammation and lipid-related detection in the diagnosis of non-small cell lung cancer(NSCLC). ［Methods］ Total 965 NSCLC patients and 464 healthy controls were randomly divided into two groups： training set and test set. The blood levels of CEA，NSE and SCC，platelet(PLT)，neutrophil and monocyte ratio(NMR)，hemoglobin(HGB)，albumin(ALB)，high-density lipoprotein cholesterol(HDL) and triglyceride(TG) were detected. The diagnostic efficiency of individual indicators was analyzed using a receiver operating curve(ROC)，and a combination diagnostic model was established in the training set using binary logistic regression，which was further validated in the test set. ［Results］ Compared with the control group，PLT，NMR and TG levels of NSCLC patients were increased，while HGB，ALB and HDL levels were significantly decreased(P<0.001). The models combined with ALB，NMR，TG，NSE and SCC were more effective for the diagnosis of NSCLC，the area under the curve(AUC) of the training set and test set was 0.910 and 0.887，the sensitivity was 83.44% and 76.76%，and the specificity was 88.26% and 86.23%，respectively. ［Conclusion］ The levels of PLT，NMR，HGB，ALB，HDL and TG are significantly different between NSCLC patients and healthy controls. The combination of ALB，NMR，TG，NSE，and SCC may improve the diagnostic efficiency of the conventional tumor markers. |
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