| 褚玉新,胡钦勇,宋启斌.衰老相关分泌表型在乳腺癌进展中的作用[J].中国肿瘤,2018,27(5):364-368. |
| 衰老相关分泌表型在乳腺癌进展中的作用 |
| Role of Senescence-associated Secretory Phenotype in the Progress of Breast Cancer |
| 投稿时间：2018-03-07 |
| DOI：10.11735/j.issn.1004-0242.2018.05.A009 |
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| 中文关键词: 乳腺癌 衰老 分泌表型 |
| 英文关键词:breast cancer senescence secretory phenotype |
| 基金项目:国家自然科学基金（81670123，81670144） |
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| 摘要点击次数: 1955 |
| 全文下载次数: 474 |
| 中文摘要: |
| 摘 要：细胞衰老在乳腺癌的发生发展中起重要作用，包括复制性细胞衰老、癌基因诱导细胞衰老、治疗诱导的细胞衰老。细胞衰老具备特异性表型，如特征性的形态变化，SA-β-gal染色阳性，形成衰老相关异染色质集落，以及产生衰老相关分泌表型。肿瘤细胞衰老相关分泌表型具有双面性，既可抑制肿瘤又可促进肿瘤进展。肿瘤细胞衰老相关分泌表型也有双向调节作用，在癌变早期主要发挥正性调节作用，而在肿瘤晚期主要发挥负性调节作用。不同类型的乳腺癌产生不同程度的衰老相关分泌表型，重塑肿瘤微环境，促进乳腺癌进展。鉴定靶向乳腺癌中衰老相关分泌表型的特异性药物将是一种很有前景的抗肿瘤策略。 |
| 英文摘要: |
| Abstract：Cellular senescence plays a vital role in the pathogenesis of breast cancer，including replicative senescence，oncogene induced senescence，therapy-induced senescence. Cellular senescence also has specific phenotypes，such as characteristic morphologic changes，positive SA-β-gal staining，senescence-associated heterochromatic foci(SAHF)，and senescence-associated secretory phenotype(SASP). The SASP in tumor cells is a double-edged sword，which can both inhibit and promote cancer progress. The SASP also has dual regulation，it has positive effect in early oncogenesis，but has negative effect in advanced tumors. Different subtypes of breast cancers produce different proportions of SASP，remodeling tumor microenvironment，rendering breast cancer progress. Characterization of specific drugs targeting SASP in breast cancer will become a prospective anti-cancer strategy. |
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