| 刘华丽,许 斌,韩 光.EGFR-TKI在非小细胞肺癌中的研究进展[J].中国肿瘤,2018,27(4):285-293. |
| EGFR-TKI在非小细胞肺癌中的研究进展 |
| Progress of EGFR-TKIs in Non-small Cell Lung Cancer |
| 投稿时间：2018-01-19 |
| DOI：10.11735/j.issn.1004-0242.2018.04.A008 |
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| 中文关键词: 非小细胞肺癌 分子靶向治疗 表皮生长因子受体酪氨酸激酶抑制剂 EGFR-TKI联合治疗模式 |
| 英文关键词:non-small cell lung cancer molecular targeted therapy epidermal growth factor tyrosine kinase inhibitor the mode of EGFR-TKI combination with other anti-cancer treatment |
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| 摘要点击次数: 2879 |
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| 中文摘要: |
| 摘 要：肺癌是引起人类恶性肿瘤相关性死亡的主要原因，也是世界范围内发病率最高的恶性肿瘤，其中非小细胞肺癌（NSCLC）是其主要类型。近年来，NSCLC的治疗取得重要突破，已由传统的手术、化疗和放疗，发展到精准分子靶向治疗时代和免疫治疗时代。NSCLC分子靶向治疗中，又以表皮生长因子酪氨酸激酶抑制剂（EGFR-TKI）研究最透彻，已广泛应用于EGFR突变人群中。一代EGFR-TKI已是EGFR突变晚期NSCLC患者的标准一线治疗。一代EGFR-TKIs药物间疗效无显著性差异，不良反应发生率上厄洛替尼相对更低。二代EGFR-TKI疗效不亚于一代EGFR-TKI，对少见突变患者具有一定疗效。三代EGFR-TKIs作为后起之秀，对EGFR突变患者（包括T790M突变）疗效显著，对脑转移患者亦有作用。新时代下EGFR-TKI联合化疗、放疗、免疫及抗肿瘤血管治疗等其他治疗模式的探索初现成果，TKI联合其他抗肿瘤治疗给患者治疗带来新的选择和方向。EGFR-TKI治疗NSCLC在挑战与机遇中砥砺前行。 |
| 英文摘要: |
| Abstract：Lung cancer is the most common malignancy and the leading cause of cancer-related death worldwide. Non-small cell lung cancer（NSCLC）is the main type of lung cancer. In recent years，the treatment of NSCLC has made important breakthroughs，from traditional surgery，chemotherapy and radiotherapy to an era of molecular-targeted therapy and immunotherapy. The epidermal growth factor tyrosine kinase inhibitor（EGFR-TKI）as the molecular-targeted therapy of NSCLC was well studied and has been widely used in EGFR mutation patients. The first generation EGFR-TKIs has been recommended as the first-line treatment for advanced NSCLC patients with EGFR mutations. There is no significant difference in clinical efficacy among different first generation EGFR-TKI drugs，while the incidence of side effects of erlotinib is relatively lower. The efficacy of the second generation EGFR-TKI is not less than the first generation EGFR-TKI，and it is effective for NSCLC patients with uncommon EGFR mutations. The third generation EGFR-TKIs are particularly effective for patients harboring activating EGFR mutations including T790M mutation，and for NSCLC patients with brain metastases. The combination of EGFR-TKIs with chemotherapy，radiotherapy，immunotherapy or anti-tumor vascular therapy has achieved promising results，it would be a new option and direction for NSCLC patients. |
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