| 李 甜,周钱梅,张卫红.PI3K/Akt/mTOR信号通路在三阴性乳腺癌治疗中的研究进展[J].中国肿瘤,2018,27(1):40-45. |
| PI3K/Akt/mTOR信号通路在三阴性乳腺癌治疗中的研究进展 |
| Advances in Research of PI3K/Akt/mTOR Signaling Pathway for Treatment of Triple Negative Breast Cancer |
| 投稿时间：2017-03-14 |
| DOI：10.11735/j.issn.1004-0242.2018.01.A006 |
|
 |
| 中文关键词: 三阴性乳腺癌 PI3K/Akt/mTOR信号通路 作用机制 治疗 |
| 英文关键词:triple negative breast cancer PI3K/Akt/mTOR signaling pathway mechanism treatment |
| 基金项目:国家自然青年科学基金 (81503578)；上海市卫生和计划生育委员会科研基金 (201540036) |
|
| 摘要点击次数: 2271 |
| 全文下载次数: 745 |
| 中文摘要: |
| 摘 要：三阴性乳腺癌是乳腺癌中的一种特殊分型，异质性强，有效作用靶点不明，具有侵袭早，转移快，预后差等特点，5年生存率低，是乳腺癌中病死率最高的一种亚型。目前已对一些潜在的分子靶点做了一些实验，但一些研究发现，PI3K/Akt/mTOR信号通路抑制剂对于三阴性乳腺癌的抑制作用更为明显，一些抑制剂已经进入了预试验或早期临床试验阶段。该文主要介绍三阴性乳腺癌的分子分型，PI3K/Akt/mTOR信号传导通路的异常激活机制及所涉及的关键基因在三阴性乳腺癌中的表达水平和相关抑制剂的治疗加以综述，以期为该类型的乳腺癌提供更好的治疗途径。 |
| 英文摘要: |
| Abstract：Triple negative breast cancer（TNBC）is a special subtype of breast carcinoma，characterized by highly invasiveness，early metastasis and poor prognosis due to its heterogeneity and lack of effective target. Recent studies have demonstrated some potential molecular targets in TNBC. The inhibitors of PI3K/Akt/mTOR pathway showed a significant effect on TNBC，and preclinical development or early phase clinical trials of several PI3K/Akt/mTOR inhibitors are on the way. This article reviews the molecular typing of TNBC，the current researches on the mechanism of abnormal activation of PI3K/Akt/mTOR signaling pathway and its related key genes，and also the effects of its inhibitors；hopefully it may offer new approach for the treatment of TNBC. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |