| 于 洋,张翠萍,王淑霞.肝癌组织中COX-2蛋白表达及其与临床病理关系的Meta分析[J].中国肿瘤,2017,26(11):915-924. |
| 肝癌组织中COX-2蛋白表达及其与临床病理关系的Meta分析 |
| COX-2 Protein Expression and Its Relation to Clinicopathological Features of Hepatocellular Carcinoma：A Meta Analysis |
| 投稿时间：2017-02-08 |
| DOI：10.11735/j.issn.1004-0242.2017.11.A014 |
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| 中文关键词: 环氧化酶?鄄2 肝癌 临床病理学 分化程度 Meta分析 |
| 英文关键词:cyclooxygenase-2 hepatocellular carcinoma clinicopathology differentiation degree Meta-analysis |
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| 中文摘要: |
| 摘 要：［目的］ 通过Meta分析评价环氧化酶-2（COX-2）在肝癌中的表达及其与临床病理特征间的关系，以期寻找肝癌早期诊断、化学预防及治疗的新型分子靶点。［方法］ 通过检索CNKI、万方、Cochrane图书馆、PubMed等数据库，搜集从建库至2016年10月国内外公开发表的有关COX-2在肝癌中表达的病例对照研究，纳入采用免疫组化法检测COX-2蛋白，并将染色范围及染色强度相结合评估其表达水平，且NOS评分量表≥5分的高质量研究。应用RevMan5.3进行系统评价及异质性分析，计算合并OR及95%CI，对存在异质性的研究进行亚组分析以探讨其来源，应用Stata12.0绘制漏斗图及Egger回归方程评估有无发表偏倚。［结果］ 共有21篇文献纳入本次系统评价，Meta分析结果显示：COX-2在肝癌组中的表达高于正常组(OR=15.69，95%CI：9.73~25.32，P<0.00001)，COX-2在癌旁组中的表达高于正常组（OR=9.47，95%CI：4.70~19.10，P<0.00001），COX-2在高分化肝癌组的表达高于中—低分化组（OR=1.97，95%CI：1.43~2.72，P<0.0001），差异均具有统计学意义。在COX-2与性别、肿瘤大小、TNM分期等其他9项肝癌临床病理特征关系的比较中，各组间差异并无统计学意义。［结论］ COX-2在肝癌中表达增高，且主要在肝癌发生的早期阶段而非进展阶段发挥作用，COX-2有望成为肝癌早期诊断、化学预防及治疗的新型分子靶点。 |
| 英文摘要: |
| Abstract：［Purpose］To evaluate the expression of COX-2 protein in hepatocellular carcinoma(HCC) and its relation to clinicopathologic features by Meta-analysis. ［Methods］ The published case-control studies about COX-2 expression in HCC were retrieved by searching CNKI，Wanfang，Cochrane library and PubMed database before October 2016. Studies were considered to be high quality if the NOS-scale score was 5 or more，including the reseaches by using immunohistochemical method to determine COX-2 and those by synthesizing staining range and staining intensity to evaluating expression level. Statistical heterogeneity evaluation and systematic review was performed by Revman 5.3，merged odds ratio（OR） and 95% confidence interval（95%CI） were calculated，subgroup analysis was performed to investigate the sources of heterogeneity. Publication bias was investigated through funnel plots and Egger’s regression model by Stata 12.0. ［Results］A total of twenty-one studies were enrolled for systematic valuation. The expression level of COX-2 in HCC tissues was significantly higher than that in normal tissues(OR=15.69，95%CI：9.73~25.32，P<0.00001)；significant differences were tested between cancer adjacent tissues and normal tissues（OR=9.47，95%CI：4.70~19.10，P<0.00001). The expression level of COX-2 in well differential HCC was higher than that in moderate-poor differentiation group（OR=1.97，95%CI：1.43~2.72，P<0.0001)；but no significant differences were found in different gender，tumor sizes，tumor stages and other clinicopathologic features. ［Conclusion］ There is over-expression of COX-2 in HCC，COX-2 may play a role in the early stage of hepatocarcinogensis，but not advanced stage. The results indicate that COX-2 mightit be used as a new molecular target for early diagnosis，chemoprevention and treatment of HCC. |
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