| 崔伟丽,李 娜,徐保华.端粒酶逆转录酶基因多态性与肝癌的易感性研究[J].中国肿瘤,2017,26(10):825-828. |
| 端粒酶逆转录酶基因多态性与肝癌的易感性研究 |
| Association of Genetic Variants of hTERT with Susceptibility to Hepatocellular Carcinoma |
| 投稿时间：2016-10-24 |
| DOI：10.11735/j.issn.1004-0242.2017.10.A015 |
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| 中文关键词: 端粒，末端转移酶 单核苷酸多态性 肝肿瘤 HBV感染 |
| 英文关键词:telomerase polymorphism,single nucleotide hepatocellular neoplasms hepatitis B virus |
| 基金项目: |
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| 中文摘要: |
| 摘 要：［目的］ 探讨人类端粒酶逆转录酶（hTERT）基因位点（rs2075786、rs2736098）单核苷酸多态性（SNP）与肝癌的易感性。［方法］ 采用聚合酶链反应—限制性片段长度多态性（PCR－RFLP）检测肝癌患者165例、非肝癌乙肝病毒感染者195例、健康对照者402名的hTERT基因型分布。［结果］ 肝癌组患者rs2075786位点TC及TT基因型频率显著高于对照组、非肝癌HBV感染者及所有非HCC者（P均<0.05），携带TC及TT基因型者罹患肝癌的风险分别增加1.88倍和2.72倍，且男性肝癌患者携带TC及TT基因型明显增加。与对照组、非肝癌HBV感染者及所有非HCC者相比，肝癌组rs2736098位点各基因型分布差异无统计学意义，多态性与肝癌患者的性别、年龄、肿瘤分化程度及TNM分期无相关性。［结论］ hTERT rs2075786基因多态性与肝癌易感性相关。 |
| 英文摘要: |
| Abstract：［Purpose］ To explore the correlation between several single-nucleotide polymorphisms(SNPs) loci on the gene of human telomerase reverse transcriptase(hTERT)(including rs2075786，rs2736098) and the susceptibility to hepatocellular carcinoma. ［Methods］ This case-control study included 165 diagnosed as hepatocellular carcinoma，195 with chronic hepatitis B and 402 Healthy people. Polymerase chain restriction fragment length polymorphism were performed to analyze the genotype of the loci on the gene of hTERT. ［Results］ The frequency of TC and TT genotype on rs2075786 were higher in the Hepatocellular carcinoma group than that in the control group，chronic hepatitis B group and no HCC people group(P<0.05)，The additive odds ratio of TT and TC genotype for the risk of Hepatocellular carcinoma was 1.88 and 2.72，and men with hepatocellular carcinoma carried more TC and TT genotype than women. The frequency of all genotype on rs2736098 was not significantly different between hepatocellular carcinoma group and control group. The single nucleotide polymorphism of rs2736098 was not associated with the gender，age，the degree of differentiation and TNM staging of hepatocellular carcinoma. ［Conclusion］ There is a relationship between hTERT rs2075786 polymorphism and susceptibility to hepatocellular carcinoma. |
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