| 孙建松,熊世珍.DNA依赖蛋白激酶在鼻咽癌病变中的表达及意义[J].中国肿瘤,2017,26(8):656-660. |
| DNA依赖蛋白激酶在鼻咽癌病变中的表达及意义 |
| Expression and Clinical Significance of DNA-dependent Protein Kinase in Nasopharyngeal Carcinoma |
| 投稿时间：2016-06-20 |
| DOI：10.11735/j.issn.1004-0242.2017.08.A013 |
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| 中文关键词: 鼻咽肿瘤 DNA依赖蛋白激酶 免疫组化 |
| 英文关键词:nasopharyngeal neoplasms DNA-dependent protein kinase(DNA-PKAcs) immunohistochemistry |
| 基金项目:贵阳市科技计划项目（筑科合同［2011103］40） |
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| 摘要点击次数: 2180 |
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| 中文摘要: |
| 摘 要：［目的］ 研究DNA依赖蛋白激酶（DNA-PKcs)在鼻咽部正常黏膜、鼻咽炎、鼻咽非典型增生及鼻咽癌中的表达，并探讨DNA-PKcs表达与鼻咽癌临床病理参数间的关系。［方法］ 应用免疫组化EnVision法检测10例鼻咽部正常黏膜、10例鼻咽炎、21例鼻咽非典型增生和53例鼻咽癌组织中DNA-PKcs蛋白的表达水平，并结合临床病理特征进行分析。［结果］ DNA-PKcs蛋白在正常鼻咽黏膜及鼻咽炎组织中呈低表达，在鼻咽非典型增生及鼻咽癌组织中呈高表达，阳性表达率分别为0、20.00％、71.42％和 64.15％；其表达与鼻咽癌组织分化类型相关(P=0.023)，与性别、年龄、临床分期及淋巴结转移无明显相关性(P均>0.05)。［结论］ DNA-PKcs在鼻咽癌病变过程中可能发挥一定的作用。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of DNA-dependent protein kinase(DNA-PKcs) in normal nasopharyngeal mucosa，nasopharyngitis，nasopharyngeal atypical hyperplasia and nasopharyngeal carcinoma(NPC)，and to analysis the relationship between DNA-PKcs protein and the clinicopathologic parameters of NPC. ［Methods］ The expression of DNA-PKcs protein in tissue samples of nasopharyngeal mucosa(n=10），nasopharyngitis(n=10)，nasopharyngeal atypical hyperplasia(n=21) and NPC(n=53) was detected by immunohistochemical technique(Envision). The relationship between DNA-PKcs expression and clinicopathological features of NPC was analyzed. ［Results］ The positive rates of DNA-PKcs in normal nasopharyngeal mucosa，nasopharyngitis，nasopharyngeal atypical hyperplasia and NPC were 0，20.00%，71.42% and 64.15%，respectively. DNA-PKcs expression was correlated with tumor differentiation(P<0.05)，but not correlated with clinical stages or neck lymph node metastasis of NPC(P>0.05). ［Conclusion］ DNA-PKcs may be involved in the carcinogenesis of nasopharyngeal neoplasms. |
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