| 李 璐.胃癌基因标志物调控网络模型的初步建立[J].中国肿瘤,2017,26(8):634-641. |
| 胃癌基因标志物调控网络模型的初步建立 |
| Preliminary Establishment of a Regulatory Network Model of Gene Markers in Gastric Cancer |
| 投稿时间：2016-09-30 |
| DOI：10.11735/j.issn.1004-0242.2017.08.A010 |
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| 中文关键词: 胃肿瘤 基因标志物 调控网络 |
| 英文关键词:gastric neoplasms gene markers regulatory network |
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| 中文摘要: |
| 摘 要：［目的］探讨胃癌基因标志物的生物学功能，并建立胃癌肿瘤细胞初级调控网络模型。［方法］ 利用GO数据库和KEGG数据库，对胃癌相关的6个基因标志物MMP-7、KISS-1、VHL、p53、PTEN、MMP-9进行生物信息学分析。GO筛选条件分别是“biological process”、“Homo sapiens”、“gene”，在KEGG中，organism的筛选条件为“hsa”，key words为MMP-7、KISS-1、VHL、p53、PTEN、MMP-9。［结果］ 综合GO功能分析和KEGG分析结果，初步建立由MMP-7、KISS-1、VHL、p53、PTEN、MMP-9基因组成的胃癌肿瘤细胞调控网络模型。［结论］ 成功构建这些基因在胃癌肿瘤细胞中的初级调控网络模型，为进一步研究胃癌发病机制、胃癌肿瘤生物靶点的筛选及分子靶向治疗奠定基础。 |
| 英文摘要: |
| Abstract：［Purpose］ To establish a regulatory network model of gene markers in gastric cancer. ［Methods］ Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Gnomes(KEGG) databases were used to conduct bioinformatics analysis on six markers related to gastric cancer including PTEN，KISS-1，VHL，p53，MMP-9 and MMP-7. Filter criteria of GO were “biological process”，“Homo sapiens”and “gene” respectively. Filter criteria of organism in KEGG was “has”，and key words were MMP-7，KISS-1，VHL，p53，PTEN and MMP-9，respectively. ［Results］ Based on the results of GO and KEGG analysis，a preliminary regulatory network model of gastric cancer cells consisting of MMP-7，KISS-1，VHL，p53，PTEN and MMP-9 genes was established. ［Conclusions］ The successful establishment of a preliminary regulatory network model of gene markers may be useful for studies on pathogenesis，biological targets，and targeted molecular therapy of gastric cancer. |
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