| 朱雨彤,孙 佳,李洪艳.岩藻糖基转移酶Ⅳ和肿瘤相关性的研究进展[J].中国肿瘤,2017,26(8):629-633. |
| 岩藻糖基转移酶Ⅳ和肿瘤相关性的研究进展 |
| Research Progress of Correlation Between Fucosyltransferase Ⅳ and Tumors |
| 投稿时间：2016-07-16 |
| DOI：10.11735/j.issn.1004-0242.2017.08.A009 |
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| 中文关键词: 岩藻糖基转移酶Ⅳ 岩藻糖基化寡糖 肿瘤 |
| 英文关键词:FUT4 fucosylated oligosaccharide tumor |
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| 中文摘要: |
| 摘 要：岩藻糖基转移酶（FUTs）是一类催化糖蛋白或糖脂岩藻糖基化的酶。目前已发现13种FUTs，其中岩藻糖基转移酶Ⅳ（FUT4）是负责催化合成岩藻糖基化寡糖Lewis X (LeX)和Lewis Y(LeY)等的关键酶。FUT4在很多上皮来源的恶性肿瘤中高表达。本文就FUT4基因在肿瘤细胞中的表达特点和调控机制，以及FUT4在肿瘤恶性发展过程中的作用作一综述，旨为肿瘤的发生发展提供理论依据，为肿瘤的诊断及治疗提供参考。 |
| 英文摘要: |
| Abstract：Fucosyltransferases (FUTs) are considered as key enzymes that regulate the synthesis of fucosylated oligosaccharides bonded to glycoproteins or glycolipids on the cells surface. It is known that 13 kinds of FUT have been cloned to date. FUT4 is one of key enzymes for the synthesis of (Lewis X) LeX and(Lewis Y) LeY. Elevated FUT4 expression has been found in many tumors of epithelial cell origin. In this review，the features of FUT4 expression and regulation in tumor cells are summarized. The role of FUT4 in tumors progression is analyzed. The aim of this review is to provide a theoretical basis for the development of tumors，and a reference for the diagnosis and treatment of tumors. |
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