| 中文关键词: 胆管肿瘤 非编码RNA 微小RNA 长链非编码RNA 环状RNA |
| 英文关键词:cholangiocarcinoma ncRNA microRNA lncRNA circular RNA |
| 基金项目:国家自然科学基金（81602088）；黑龙江省卫生计生委科研课题（2016-049）；黑龙江省博士后资助课题（LBH-Z16096）；哈尔滨医科大学创新科学研究基金（2016LCZX09） |
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| 中文摘要: |
| 摘 要：胆管癌是起源于胆管上皮细胞的恶性肿瘤，该疾病具有高度致死性且发病率逐年增加。机制及病因不清使该病诊疗困难。随着生物信息学的发展，越来越多的研究发现非编码RNA（ncRNA）与胆管癌病理生理过程密切相关并且作为潜在的肿瘤标志物和治疗位点而备受关注。全文将胆管癌中非编码RNA的研究成果作以综述。 |
| 英文摘要: |
| Abstract：Originating from bile ducts，cholangiocarcinoma is an epithelial malignant cancer with high mortality and rising incidence. Less understanding of its etiology and pathogenesis makes the diagnosis and treatment difficult. With the development of bioinformatics，more and more studies have found that ncRNA were closely related to its tumorigenesis. And the potential of ncRNA to be biomarkers and therapy targets is great attractive. In this article，we summarize the latest advances of ncRNAs in cholangiocarcinoma. |
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