| 陈 丹,王凯冰,李加桩.血清VEGFR-2浓度变化预测肝癌患者TACE近期疗效的研究[J].中国肿瘤,2017,26(6):476-481. |
| 血清VEGFR-2浓度变化预测肝癌患者TACE近期疗效的研究 |
| Prediction of Serum VEGFR-2 Concentration on the Short-term Effects of TACE in Patients with Hepatocellular Carcinoma |
| 投稿时间：2016-10-20 |
| DOI：10.11735/j.issn.1004-0242.2017.06.A012 |
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| 中文关键词: 肝肿瘤 TACE VEGFR-2 酶联免疫吸附法 |
| 英文关键词:hepatocellular neoplasms TACE VEGFR-2 ELISA |
| 基金项目:吴阶平医学基金会临床科研专项资助基金（320.6750.15179） |
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| 中文摘要: |
| 摘 要：［目的］ 研究血清VEGFR-2浓度变化与肝癌患者经肝动脉化疗栓塞术（TACE）治疗后近期疗效的相关性。［方法］ 采用ELISA方法检测24例晚期肝癌患者TACE治疗前后血清VEGFR-2的表达水平，并分析VEGFR-2浓度变化与晚期肝癌患者临床病理的关系。［结果］ 血清VEGFR-2浓度与肿瘤数目、肝硬化病史有关(P＜0.05)；PFS与肿瘤数目、门脉癌栓、肿瘤大小、肝硬化有关(P＜0.05)。治疗1个月后疾病缓解5例，疾病稳定14例，疾病进展5例，mPFS分别为7.84、4.78、3.68个月(P＜0.05)。［结论］ TACE术后1个月血清VEGFR-2浓度变化与PFS有关，血清VEGFR-2浓度变化可能成为肝癌TACE治疗潜在的近期疗效预测指标。 |
| 英文摘要: |
| Abstract：［Purpose］ To study the correlation between the changes of serum VEGFR-2 concentration and short-term effects of hepatocellular carcinoma after transcatheter arterial chemoembolization. ［Methods］ Serum VEGF-2 expression level，measured by quatitative sandwich enzyme-linked immunosorbentassay(ELISA)，was measured before TACE 1 day and 1 month after TACE in 24 patients with HCC and the correlation between the change of VEGFR-2 concentration and clinical pathological characteristics of patients with advanced hepatocellular carcinoma was analyzed. ［Results］ The serum VEGFR-2 concentration was significantly correlated with the tumor size and hepatic cirrhosis(P<0.05). The progress free survival(PFS) was significantly correlated with the tumor size，portal vein invasion，tumer number and hepatic cirrhosis(P<0.05). There were 5 patients with partial response after one month of treatment，14 patients with stable disease，5 patients with progressive disease. The PFS was 7.84，4.71 and 3.68 months，respectively(P<0.05). ［Conclusion］ The change of serum VEGFR-2 concentration in early stage is related to PFS and VEGFR-2 may be a potential indicator for predicting the short-term effects of TACE in hepatocellular carcinoma. |
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