| 范振列,杨 召,乔友林.109例直肠神经内分泌肿瘤患者的临床病理特征与预后分析[J].中国肿瘤,2017,26(4):308-314. |
| 109例直肠神经内分泌肿瘤患者的临床病理特征与预后分析 |
| Clinicopathological Characteristics and Prognosis of Rectal Neuroendocrine Tumors |
| 投稿时间：2016-09-19 |
| DOI：10.11735/j.issn.1004-0242.2017.04.A013 |
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| 中文关键词: 直肠神经内分泌肿瘤 临床病理特征 预后 |
| 英文关键词:rectal neuroendocrine tumor clinical pathological characteristics prognosis |
| 基金项目:辉瑞公司胃肠胰腺神经内分泌肿瘤临床流行病学研究专项基金（WS1910269） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨直肠神经内分泌肿瘤的临床病理特征及预后。［方法］ 回顾性分析109例直肠神经内分泌肿瘤患者的临床病理及随访资料。观察患者肿瘤的分类情况，并通过Kaplan-Meier法估计受试者的预后生存情况，利用Cox等比例风险模型来探讨影响直肠神经内分泌肿瘤预后的危险因素。［结果］ 109例直肠神经内分泌肿瘤患者，其中神经内分泌肿瘤患者91例(83.48%)、神经内分泌癌患者和未知分级患者各9例(8.26%)。患者的平均年龄（50.58±11.90）岁，男、女性别比为1.51∶1，且多数患者(90.83%)居住在城镇。经过8.12年(中位随访时间，95%CI：7.32~8.85年)的随访，全组患者的3年、5年和10年生存率分别为91.23%(95%CI：83.83%~95.34%)、88.20%(95%CI：80.14%~93.12%)和84.20%(95%CI：74.85%~90.29%)。Cox等比例风险模型的结果显示，年龄(HR=5.80，95%CI：1.36~24.77)、淋巴结转移(HR=7.15， 95%CI：2.27~24.83)和远处转移(HR=7.42，95%CI：1.98~27.76)是影响直肠神经内分泌肿瘤预后的独立危险因素。［结论］ 直肠神经内分泌肿瘤多发生于城镇地区的中年男性人群，预后较好。年龄、淋巴结转移和远处转移是直肠神经内分泌肿瘤预后的独立危险因素。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the clinicopathological characteristics and prognosis of rectal neuroendocrine tumor(RNET). ［Methods］ The clinical and pathological characteristics and prognosis of 109 patients with RNET were retrospectively analyzed. Kaplan-Meier method was used to calculate the overall 3-，5- and 10- year survival rate and Cox proportional hazard model was applied to analyze the prognostic factors. ［Results］ A total of 109 patients were included in the final analysis，including 91 cases(83.48%) of neuroendocrine tumor(NET)，9 cases(8.26%) of neuroendocrine carcinoma(NEC) and 9 cases(8.26%) of unknown classification. The average age at diagnosis was(50.58±11.90) years，male/female ratio was 1.51 and most cases were residents living in the urban area. The median follow-up duration was 8.12(95%CI：7.32~8.85) years；the 3-，5- and 10-year overall survival rates were 91.23%(95%CI：83.83%~95.34%)，88.20%(95%CI：80.14%~93.12%) and 84.20%(95%CI：74.85%~90.29%)，respectively. Cox proportional hazard model showed that age(HR=5.80，95%CI：1.36~24.77)，lymph node metastasis(HR=7.15，95%CI：2.27~24.83) and distant metastasis(HR=7.42，95%CI：1.98~27.76) were independent prognostic risk factors of RNET. ［Conclusion］ RENT usually occur in older(≥ 60 years old)，male and urban residents with a good prognosis. Age，lymph node metastasis and distant metastasis are independent prognostic risk factors of RNET. |
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