| 郑红艳,李加桩,鲍永霞.LncRNA：非小细胞肺癌诊断治疗的新策略[J].中国肿瘤,2017,26(4):272-278. |
| LncRNA：非小细胞肺癌诊断治疗的新策略 |
| Long Non-coding RNA:A Novel Target for Diagnosis and Treatment of Non-small Cell Lung Cancer |
| 投稿时间：2016-06-07 |
| DOI：10.11735/j.issn.1004-0242.2017.04.A007 |
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| 中文关键词: NSCLC lncRNA 生物标志物 治疗靶点 |
| 英文关键词:NSCLC lncRNA biomarkers therapeutic targets |
| 基金项目: |
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| 中文摘要: |
| 摘 要：肺癌是全球最常见的恶性肿瘤，是全世界癌症相关死亡的主要原因。LncRNA是指一类至少包含200个核苷酸且不具有编码蛋白质功能的RNA。许多lncRNA都具有促进或抑制NSCLC发展及恶化的功能。由于其调节基因表达方面的基础作用，连同其在肿瘤生成的生物学机制，它们是一类有前途的组织或血液生物标志物。本文我们强调lncRNA在NSCLC的新兴作用，并讨论其作为诊断和预后的生物标志物及治疗靶点的潜在临床应用。 |
| 英文摘要: |
| Abstract：Lung cancer is a common malignant tumor and the major cause of cancer death worldwide. Long non-coding RNA (lncRNA) is the RNA with at least 200 nucleotides in length. Evidence shows that a variety of lncRNAs can promote or inhibit tumor development and progression in the non-small cell lung cancer. Due to their fundamental role in regulating gene expression and involvement in biological mechanisms underlying the tumorigenesis，lncRNAs are expected to be novel tissue or blood cancer biomarkers. In this review，we focus on the roles of lncRNAs in NSCLC，and discuss their potential clinical application as diagnostic and prognostic markers and as therapeutic targets. |
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