| 郝宝岚,王 艳,叶昱坪.乳腺良恶性疾病患者血栓弹力图检测价值[J].中国肿瘤,2017,26(3):236-240. |
| 乳腺良恶性疾病患者血栓弹力图检测价值 |
| Application of Thrombelastography in Patients with Benign and Malignant Breast Lesions |
| 投稿时间：2016-11-30 |
| DOI：10.11735/j.issn.1004-0242.2017.03.A014 |
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| 中文关键词: 血栓弹力图 凝血功能 乳腺癌 高凝状态 良性病变 |
| 英文关键词:thrombelastography(TEG) coagulation function breast cancer hypercoagulable state benign diseases |
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| 摘要点击次数: 1907 |
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| 中文摘要: |
| 摘 要：［目的］ 用血栓弹力图(TEG)和传统的凝血功能检测对乳腺良恶性疾病患者的凝血功能进行测定，评估TEG的检测价值。［方法］ 对268例乳腺癌(实验组)和45例乳腺良性病变患者(对照组)进行TEG检测和凝血四项检测［血浆凝血酶原时间（PT）、部分凝血活酶时间（APTT）、凝血酶时间（TT）和纤维蛋白原（Fib）］，同时计数血小板（PLT）及测定D-二聚体（D-dimer），根据各项参数了解其凝血状态。［结果］ 传统凝血功能检测结果：实验组的PT明显缩短，PLT、Fib与D-二聚体水平较对照组有明显增高(P＜0.05)，而APTT、TT与对照组相比无统计学差异(P＞0.05)。TEG检测结果中，实验组各个参数测量值水平和对照组相比：R 值没有明显差异(P＞0.05)， Angle 值接近显著性差异(P=0.055)，K值明显减小，MA值和CI值明显增大(P＜0.05)，支持实验组血液的高凝状态；从测量数值超出正常范围的高凝例数来看，K值和CI值在两组比较中有显著性差异(P＜0.05)； R 值、Angle 值、MA值两组中没有显著性差异(P＞0.05)。［结论］乳腺癌患者相比良性病变患者血液高凝的表现较为明显，TEG可用来监测患者围术期凝血功能，预防血栓栓塞并发症的发生。 |
| 英文摘要: |
| Abstract：［Purpose］ To assess the thrombelastography(TEG) in testing coagulation function of patients with benign and malignant breast lesions.［Methods］ Two hundred and sixty eight patients with breast cancer(cancer group) and 45 patients with benign breast lesions(benign group) were enrolled in the study. The coagulation state of patients was tested with TEG and the TEG results were compared with conventional tests，including prothrombin time(PT)，activated partial thromboplastin time(APTT)，thrombin time(TT)，fibrinogen(Fib)，D-dimer and platelets(PLT). ［Results］ There were no significant differences in TT and APTT between cancer and benign groups，while PT was significantly shortened，and D-dimer，Fib，PLT in cancer group were higher than those in benign group(all P<0.05). The average level of K in TEG was significantly lower，while MA and CI were significantly higher than those in benign group(all P＜0.05)；angle was close to the significant difference(P=0.055). In patients with high coagulation state，there were a significant differences in K and CI values between two groups(P<0.05). ［Conclusion］ Breast cancer patients often show high coagulation state compared to patients with benign breast lesions. TEG can be used to detect coagulation function for prevention of thromboembolic events. |
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