| 魏斐斐,谢裕安.肝癌相关单核苷酸多态性的研究进展[J].中国肿瘤,2017,26(3):196-202. |
| 肝癌相关单核苷酸多态性的研究进展 |
| Research Progress on Hepatocellular Carcinoma-related Single Nucleotide Polymorphism |
| 投稿时间：2016-05-13 |
| DOI：10.11735/j.issn.1004-0242.2017.03.A007 |
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| 中文关键词: 肝癌 单核苷酸多态性 遗传易感性 治疗 预后 |
| 英文关键词:hepatocellular carcinoma single nucleotide polymorphism hereditary susceptibility treatment prognosis |
| 基金项目:国家自然科学基金资助项目（81260320） |
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| 摘要点击次数: 1957 |
| 全文下载次数: 781 |
| 中文摘要: |
| 摘 要：单核苷酸多态性(single nucleotide polymorphism，SNP)作为第3代遗传标记，有助于解释不同群体和个体对肿瘤的易感性以及对治疗预后的敏感性差异。除了环境等外在综合致癌因素外，肝癌的发生和发展很大程度上与个体间基因型的遗传多态性密切相关。全文综述了SNP与肝癌易感性、治疗及预后之间的关系。 |
| 英文摘要: |
| Abstract：Single nucleotide polymorphism（SNP） is the third generation of genetic maker，which might be associated with tumor susceptibility and prognosis. The occurrence and development of HCC is not only related to environmental carcinogens，but also closely related to genetic polymorphism of individual. This paper reviews the relationship between the SNP and the susceptibility to HCC，treatment and prognosis. |
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