| 罗 扬,王文娜,徐兵河.乳腺导管原位癌伴早期浸润79例临床分析[J].中国肿瘤,2017,26(2):140-144. |
| 乳腺导管原位癌伴早期浸润79例临床分析 |
| Breast Ductal Carcimona in Situ with Early Invasion：Clinical Analysis of 79 Cases |
| 投稿时间：2016-07-03 |
| DOI：10.11735/j.issn.1004-0242.2017.02.A013 |
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| 中文关键词: 导管原位癌 早期浸润 预后 治疗 |
| 英文关键词:ductal carcioma in situ early invasion prognosis treatment |
| 基金项目: |
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| 中文摘要: |
| 摘 要：［目的］ 探讨乳腺导管原位癌伴早期浸润（DCIS-Ei）的临床特征和预后。［方法］ 回顾性收集1999年1月至2005年12月收治的79例不伴腋窝淋巴结转移的乳腺DCIS-Ei患者的临床资料，应用单因素分析影响预后的因素。［结果］ 中位随访时间为10.3年，3例患者出现乳腺癌相关复发（BCRR），包括1例区域淋巴结转移，1例同时出现区域淋巴结和远处转移，1例对侧原发乳腺癌。10年累积BCRR率为5.3%。单因素预后分析结果显示，病灶＞5.0cm (P=0.004)和原位癌成分内分泌受体（HR）阴性（P=0.011）是显著增加BCRR的因素。 ［结论］ 乳腺DCIS-Ei的长期预后良好，很少出现BCRR，病灶＞5.0cm和HR阴性者容易发生BCRR。 |
| 英文摘要: |
| Abstract：［Purpose］ To explore the clinical characteristics and prognosis of breast ductal carcinoma in situ with early invasion (DCIS-Ei) . ［Methods］ In this retrospective study，the clinical data of 79 DCIS-Ei patients with axillary node-negative were collected between January 1999 and December 2005. Univariate analysis was used to examine the prognostic factors. ［Results］ Median follow-up was 10.3 years，3 of the 79 patients had breast cancer-related recurrence(BCRR)，with 1 case of regional nodal recurrence，1 case of concurrent regional nodal/distant recurrences，and 1 case of contralateral primary breast cancer. The 10-year cumulative BCRR rate was 5.3%. In univariate analysis，lesion size＞5.0cm (P=0.004) and hormonal receptor(HR) negative of the in situ component(P=0.011) were significantly associated with an increased risk of BCRR. ［Conclusions］ DCIS-Ei has a favorable prognosis with few BCRR after a long period of follow-up. Those patients with lesion size＞5.0cm and HR negative are more likely to have BCRR. |
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