| 中文关键词: Gab1 肿瘤 生长因子受体结合蛋白 |
| 英文关键词:Gab1 neoplasms growth factor receptor binding protein |
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| 中文摘要: |
| 摘 要：Gab蛋白是一类重要的接头蛋白，该家族能与生长因子受体结合蛋白2 (growth factor receptor binding protein 2，Grb2)相结合。Gab1是哺乳动物中含量最多、分布最广的Gab蛋白，可通过与各类生长因子、细胞活素类等相互作用来放大和整合信号转导，主要通过RAS-ERK和PI3K-AKT这两条经典途径实现促进细胞生长和分化、控制凋亡、调节免疫等多种生物学功能。研究表明Gab1蛋白与肿瘤的发生、发展以及预后密切相关。全文就Gab1蛋白的结构功能、参与信号转导的作用机制以及在肿瘤中的研究进展进行综述。 |
| 英文摘要: |
| Abstract：Gab proteins，growth factor receptor binding protein 2(Grb2)-associated binder，are important scaffolding adapter proteins. Gab1，the most abundant Gab proteins in mammals，is involved in the amplification and integration of signal transduction evoked by a variety of extracellular stimuli，including various growth factors and cytokines. They are known to play key roles in many biological processes，including cell growth and differentiation，apoptosis and immune regulation，through the two classical signal pathways，RAS-ERK and PI3K-AKT. Some studies have indicated that Gab1 protein is closely related to the occurrence，development and prognosis of tumor. The structure，function and mechanism of action of the Gab1 of scaffolding adapter，with a special focus on its research progress in cancer were reviewed in this paper. |
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