| 赵 芳,王 静,余建军.microRNA表达与乳腺癌患者临床特征的关系[J].中国肿瘤,2016,25(12):1013-1017. |
| microRNA表达与乳腺癌患者临床特征的关系 |
| MicroRNA Expression and Its Relationship with Clinicopathological Characteristics of Patients with Breast Cancer |
| 投稿时间：2016-03-22 |
| DOI：10.11735/j.issn.1004-0242.2016.12.A014 |
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| 中文关键词: 乳腺癌 microRNA 临床病理 |
| 英文关键词:breast cancer microRNA clinical pathology |
| 基金项目:宁夏自然科学基金(NZ14071) |
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| 摘要点击次数: 1782 |
| 全文下载次数: 695 |
| 中文摘要: |
| 摘 要：［目的］ 探讨Let-7a、miRNA-125b、miRNA-145、miRNA-21和miRNA-155在乳腺癌组织和乳腺良性组织中的差异表达，分析其表达水平与患者临床特征的相关性。［方法］ 采用ViiATM7实时荧光定量PCR系统对miRNAs的表达水平进行检测。［结果］ Let-7a和miRNA-145在乳腺癌组织中的表达低于良性组织，差异有统计学意义（P=0.000）。Let-7a、miRNA-125、miRNA-155、miRNA-21、miRNA-145的相对表达量在不同临床分期乳腺癌组织中表达差异无统计学意义。乳腺癌组织中let-7a、miRNA-125、miRNA-145的相对表达量在不同的ER、PR、HER-2组中差异均无统计学意义。乳腺癌组织中miRNA-155的相对表达量在不同的PR组（P=0.009）中差异有统计学意义；乳腺癌组织中miRNA-21的相对表达量在不同的PR组（P=0.037）中差异有统计学意义。［结论］ miRNA-145和let-7a在乳腺癌组织中表达下调可能与乳腺癌的发生有关。miRNA-155、miRNA-21表达可能与PR有关。 |
| 英文摘要: |
| Abstract：［Purpose］ To discuss the expression of Let-7a，miRNA-125b，miRNA-145，miRNA-21 and miRNA-155 in breast cancer tissue and benign breast tissue and clinicopathological characteristics of patients with breast cancer.［Methods］ ViiATM7 real-time fluorescence quantitative PCR system was used to detect the expression levels of miRNA. ［Results］ Agent let-7a and miRNA-145 was lower in breast cancer tissue than that in the benign group，the difference was statistically significant(P=0.000). There was no significant difference of Let-7a，miRNA-125，miRNA-155，miRNA-21，and miRNA-145 in different clinical stages in breast cancer tissue. Relative expression of MiRNA-155 in breast cancer tissue in PR group was statistically significant(P=0.009). Relative expression of miRNA-21 in PR group was statistically significant(P=0.037).［Conclusion］ Deregulation of miRNA-145 and let-7a in breast cancer tissue may be associated with the occurrence of breast cancer. The expression of miRNA-155 and miRNA-21 may be associated with PR. |
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