| 骆莉萍,王卫星.Keap1在乳腺癌组织中的表达及临床意义[J].中国肿瘤,2016,25(12):1009-1012. |
| Keap1在乳腺癌组织中的表达及临床意义 |
| Expression of Keap1 in Breast Cancer Tissues and Its Clinical Significance |
| 投稿时间：2016-02-24 |
| DOI：10.11735/j.issn.1004-0242.2016.12.A013 |
|
 |
| 中文关键词: Keap1 乳腺癌 相关性 免疫组化 |
| 英文关键词:Keap1 breast cancer correlation immunohistochemistry |
| 基金项目:湖北省卫生厅科研基金项目（JX3A14） |
|
| 摘要点击次数: 1778 |
| 全文下载次数: 561 |
| 中文摘要: |
| 摘 要：［目的］ 探讨Keap1在乳腺癌组织中的表达。［方法］ 选取2013年1月至2015年12月在武汉市武昌医院肿瘤科收治的原发乳腺肿瘤患者，其中病理诊断为乳腺癌80例(乳腺癌组)和乳腺良性肿瘤300例(乳腺良性肿瘤组)，两组都进行Keap1的免疫组化分析与临床资料的调查分析。［结果］ 乳腺癌组的Keap1阳性表达率为70.0%，乳腺良性肿瘤组为7.8%，乳腺癌组的Keap1阳性表达率明显高于乳腺良性肿瘤组(P<0.05)。在80例乳腺癌患者中，Keap1的阳性表达与患者的病理类型、临床分期、淋巴结转移情况等有相关性(P<0.05)。多元回归Logistic分析结果显示，临床分期、淋巴结转移与病理类型是影响乳腺癌患者Keap1阳性表达的主要独立危险因素(P<0.05)。［结论］ Keap1在乳腺癌组织中呈现高表达，且与患者的临床分期、淋巴结转移与病理类型明显相关，参与乳腺癌的发生与发展。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the Keap1 expression in breast cancer. ［Methods］ From January 2013 to December 2015 in our hospital oncology department，80 patients were diagnosed as breast cancer(breast cancer group) and 300 patients of benign breast tumor(benign breast tumor group) were selected，all patients were carried out clinical data investigation and Keap1 immunohistochemical analysis. ［Results］ The Keap1 positive expression rate in the breast cancer group was 70.0%，while in the benign breast tumor group was 7.8%，the Keap1 positive expression rate in the breast cancer group was significantly higher than that in benign breast tumor group(P<0.05). In the 80 patients with breast cancer，the Keap1 positive expression were significantly correlated to the type of disease，clinical stage，lymph node metastasis(P<0.05). Logistic regression analysis showed that clinical stage，lymph node metastasis and type of disease were the major independent risk factors affecting the expression of Keap1 in the breast cancer(P<0.05). ［Conclusion］ Keap1 is highly expressed in breast cancer tissue and the patient’s type of disease，clinical stage，lymph node metastasis are significantly associated with the Keap1 positive expression，which participate in the occurrence and development of breast cancer. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |