| 张庆勇,朱武飞,付 晶.非编码长链RNA作为肿瘤标志物的研究进展[J].中国肿瘤,2016,25(12):984-987. |
| 非编码长链RNA作为肿瘤标志物的研究进展 |
| Research Progress in Long Non-coding RNA as Tumor Marker |
| 投稿时间：2015-11-05 |
| DOI：10.11735/j.issn.1004-0242.2016.12.A008 |
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| 中文关键词: 非编码长链RNA 肿瘤 肿瘤标志物 |
| 英文关键词:long non-coding RNA tumor tumor markers |
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| 摘要点击次数: 1784 |
| 全文下载次数: 541 |
| 中文摘要: |
| 摘 要：非编码长链RNA（lncRNA）是指一类长度大于200个核苷酸的长链RNA分子，lncRNA在真核细胞基因组中被普遍转录，占基因组转录物的绝大部分，其数量巨大，种类繁多，但无蛋白质编码功能，相对于研究较多的microRNA，lncRNA的功能目前尚不完全清楚。近年越来越多的研究发现，lncRNA可在多个水平调控基因的表达，在肿瘤的发生发展过程中起着重要作用，在肿瘤组织中存在一些lncRNA的异常表达，这些异常表达具有肿瘤特异性。lncRNA有希望作为肿瘤标志物用于肿瘤的早期诊断及预后评估。全文就近年关于lncRNA作为肿瘤标志物研究成果作一综述。 |
| 英文摘要: |
| Abstract：Long non-coding RNA (lncRNA) refers to a class of length greater than 200 nucleotides long-chain RNA molecules，lncRNA is generally transcribed in eukaryotic genomes，accounts for most of the genome transcript，with a huge variety number，but no protein-coding function，compared to microRNA，lncRNA function is not very clear. But in recent years，a growing number of studies have found，lncRNA can regulate gene expression at multiple levels，which plays an important role in the development of tumors. Recent studies have found that abnormal expression of lncRNA in the tumor tissue，which is the tumor-specific，therefore，lncRNA promising as a tumor marker for early diagnosis and prognosis of tumors. This article reviews lncRNA researches as a tumor marker in recent years. |
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