| 中文关键词: 钙网蛋白 热休克蛋白 ATP Ⅰ型干扰素 HMGB1 |
| 英文关键词:calreticulin HSPs ATP type Ⅰ interferon HMGB1 |
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| 中文摘要: |
| 摘 要：放化疗、靶向治疗能够引起的治疗性相关免疫反应可以对抗恶变肿瘤细胞，这种现象被称为“免疫原性死亡”。濒临凋亡的细胞只有在细胞压力的作用下发射一系列免疫信号才能称之为免疫原性死亡。这些免疫信号被称为损伤相关分子模式（damage-associated molecular patterns，DAMPs）。全文综述钙网蛋白、热休克蛋白、ATP等几类重要的DAMPs及对临床治疗的影响，为肿瘤临床治疗提供参考意义。 |
| 英文摘要: |
| Abstract：Conventional chemotherapeutics，radiotherapy and targeted anticancer agents can provoke a therapeutically relevant，adaptive immune response against malignant cells ，which is commonly known as “immunogenic cell death.” Dying cancer cells are perceived as immunogenic only when they emit a set of immunostimulatory signals upon the activation of intracellular stress response pathways. The emission of these signals are generally referred to “damage-associated molecular patterns” (DAMPs). In this paper，we reviewed DAMPs including calreticulin，HSPs，ATP and so on，which indicated that DAMPs might have prognostic or predictive value for cancer patients. |
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