| 中文关键词: 胃癌 分子分型 信号通路 |
| 英文关键词:gastric cancer molecular classification signal pathway |
| 基金项目:国家自然科学基金 (81201876)；黑龙江省自然科学基金 (QC2012C011)；黑龙江省卫生厅资助项目(688) |
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| 中文摘要: |
| 摘 要：胃癌是全球性常见的恶性肿瘤。胃癌是一种异质性疾病包括多种类型，每种类型都有不同的生物学特性和作用。因此，基于临床特点，病理分型，分子分型的个体化治疗对进展期胃癌尤为重要。现有的胃癌分子分型可归类为Shah分型，Tan基因分型，新加坡基因分型，TCGA基因分型和ACRG基因分型。从分子生物学创立引起肿瘤治疗模式的变化，从分子水平重新认识疾病，未来的肿瘤治疗模式可能是分子分型指导的个体化治疗。 |
| 英文摘要: |
| Abstract：Gastric cancer is a highly heterogeneous disease comprising multiple subtypes and each type has distinct biological properties. Therefore，it is particularly important to treat advanced gastric cancer patients with individualized approach based on clinical features，pathological classification and molecular classification. The current molecular classifications of gastric cancer include Shah parting，Tan genotyping，Singapore genotyping，TCGA genotyping and ACRG genotyping. With the development of molecular biology and new knowledge of malignancies，the future therapeutic mode for gastric cancer would be a molecular classification-guided individualized approach. |
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