| 唐建宁,张艳桥,李志伟.胃癌D2根治术后辅助化疗起始时间与预后的关系[J].中国肿瘤,2016,25(8):663-666. |
| 胃癌D2根治术后辅助化疗起始时间与预后的关系 |
| Relationship Between Initiation Time of Adjuvant Chemotherapy and Survival in Gastric Cancer Patients with D2 Resectable |
| 投稿时间：2015-12-12 |
| DOI：10.11735/j.issn.1004-0242.2016.08.A016 |
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| 中文关键词: 胃癌 辅助化疗 起始时间 生存期 |
| 英文关键词:gastric cancer adjuvant chemotherapy time to initiation overall survival |
| 基金项目: |
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| 摘要点击次数: 1935 |
| 全文下载次数: 510 |
| 中文摘要: |
| 摘 要：［目的］ 探讨胃癌D2根治术后化疗起始时间与患者预后的关系。［方法］ 对我院2007~2011年间298例胃癌D2根治术后接受辅助化疗的患者进行了随访及系统分析。根据手术距辅助化疗开始的时间（≤45d和>45d）分析化疗起始时间与预后间的关系。［结果］ 298例患者中化疗开始时间≤45d，233例（78%），开始时间>45d65例（22%）。全组患者3年生存率为55.3%，5年生存率为9.6%。多因素分析显示化疗起始时间是胃癌患者的独立预后因素。［结论］ 胃癌D2根治术后最佳化疗开始时间应在45d内，延迟辅助化疗开始时间（>45d）可能与患者生存率降低有关。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the association between initiation time to adjuvant chemotherapy and survival in patients with gastric cancer. ［Methods］ A total of 298 cases of gastric cancer with D2 resectable from The Affliated Tumor Hospital of Harbin Medical University between 2008 and 2011 were enrolled in this study. The survival was estimated by Kaplan-Meier method and compared with Log-rank method. COX proportional hazards model was used for multivariate analysis.［Results］ Of 298 patients，233(78%) cases started adjuvant chemotherapy within 45 days after surgery and 65(22%) cases started adjuvant chemotherapy more than 45 days after surgery. The 3-year overall survival was 55.3%，and the 5-year OS was 9.6%. Multivariate analysis showed that early initiation of adjuvant chemotherapy was an independent prognostic factor of OS(P<0.05). ［Conclusions］ It is supposed to conduct adjuvant chemotherapy within 45 days after surgery，adjuvant chemotherapy for longer than 45 days after surgery may be associated with poorer survival in patients with resectable gastric cancer. |
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