| 张 婷.基于Integrity数据库的天然抗肿瘤药发展态势研究[J].中国肿瘤,2016,25(8):639-648. |
| 基于Integrity数据库的天然抗肿瘤药发展态势研究 |
| Development Trend of Natural Antineoplastic Agents Based on Integrity Database |
| 投稿时间：2015-12-03 |
| DOI：10.11735/j.issn.1004-0242.2016.08.A012 |
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| 中文关键词: Integrity数据库 天然抗肿瘤药 计量分析 发展态势 |
| 英文关键词:Integrity database natural antineoplastic agents bibliometrics development trends |
| 基金项目:北京协和医学院协和青年基金和中央高校基本科研业务费专项（3332013151），中国医学科学院/北京协和医学院药物研究所 天然药物活性物质与功能国家重点实验室开放课题（GTZK201508） |
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| 摘要点击次数: 2012 |
| 全文下载次数: 571 |
| 中文摘要: |
| 摘 要：［目的］ 基于Integrity数据库的药物信息分析天然抗肿瘤药的发展态势。［方法］ 在Integrity数据库中对天然抗肿瘤药的药物信息进行检索、采集、清洗，采用文献计量学方法从研发阶段、治疗领域、化合物类型等多个方面对天然抗肿瘤药研发现状和发展态势进行深入分析。［结果］ Integrity数据库中收录天然抗肿瘤药物信息有4403条，其中3291条药物信息涉及先导化合物；研究发现，处于生物学实验阶段的药物最多，有3051个；从治疗领域来看，溶瘤药物的数量最多（3258个），其次是抗肿瘤抗生素（504个）和化学预防剂（215个）；植物（2646个）是天然抗肿瘤药的主要天然来源；化合物类型以生物碱（332个）、类固醇（323个）和皂苷（304个）为主；作用靶点有300多种，其中Na + / K + -ATP酶是药物作用最多的靶点，有153个；从作用机制看，有300多种分子机制，其中一氧化氮生成抑制剂（140个）和NF-κB活化抑制剂（107个）数量优势明显；细胞机制有30多种，以细胞凋亡诱导剂（728个）和信号转导调控剂（679个）为主；注射剂（149个）是最主要的给药途径。［结论］ 天然抗肿瘤药是肿瘤领域非常重要的研究方向。通过对天然抗肿瘤药的药物信息进行深入分析，可以了解该领域的研究现状和发展态势，为肿瘤研究和新药研发提供一定的借鉴和参考。 |
| 英文摘要: |
| Abstract：［Purpose］ To discuss the situation and development trend of natural antineoplastic agents based on Integrity database. ［Methods］ This paper retrieved medicine information of natural antineoplastic agents in the Integrity database，cleaned and analyzed the data，and discussed the development trend from development status，therapeutic group，product category and other aspects with the method of bibliometrics. ［Results］ There were 4403 records，including 3291 lead compounds. 3051 drugs were in biological test stage with the most quantities. From the view of therapeutic group，the largest number of drugs were oncolytic drugs (3258)，followed by antineoplastic antibiotics (504) and chemopreventive agents (215). Plants (2646) were the main natural sources. Product categories were mainly alkaloid (332)，steroids (323) and saponins (304). There were over 300 kinds of targets，including Na+/K+-ATPase with the largest amount of 153. Referring to the mechanisms，there were more than 300 kinds of molecular mechanisms，and nitric oxide inhibitors (140) and NF-κB activation inhibitor(107) had the obvious number advantages；there were more than 30 kinds of cellular mechanisms，being mostly apoptosis inducers (728) and signal transduction modulators (679). Injection (149) was the main administration route. ［Conclusion］ Natural antineoplastic agents are very important in cancer research. The deep analysis of medicine information could help to understand the current situation and development trend in this field，and also to provide some references for cancer research and drug discovery. |
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