| 苏采峰,刘 妞,张 倩.山西省襄垣县采用careHPV检测技术进行宫颈癌初筛的效果分析[J].中国肿瘤,2016,25(8):608-611. |
| 山西省襄垣县采用careHPV检测技术进行宫颈癌初筛的效果分析 |
| Analysis on the Effect of careHPV Test for Cervical Cancer Screening in Xiangyuan County，Shanxi Province |
| 投稿时间：2016-01-22 |
| DOI：10.11735/j.issn.1004-0242.2016.08.A006 |
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| 中文关键词: 人乳头瘤病毒 careHPV检测 宫颈癌 筛查 检出率 |
| 英文关键词:human papillomavirus careHPV test cervical cancer screening detection rate |
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| 中文摘要: |
| 摘 要：［目的］ 评价careHPV检测技术在农村宫颈癌筛查中的应用情况。［方法］ 对山西襄垣县2270名35~64岁妇女采用careHPV检测技术进行宫颈癌初筛，初筛阳性者接受液基细胞学分流，分流阳性者召回阴道镜检查及活检，以病理结果为金标准。［结果］ 参加筛查的妇女平均年龄45.7±6.8岁，careHPV阳性率为12.9%(292/2270)，阴道镜转诊率为4.8%(109/2270)，CIN1、 CIN2+检出率分别为1.4%(31/2270)和1.7%(38/2270)。在既往筛查史上，参加过筛查的妇女CIN2+的检出率要低于从未参加过筛查的妇女(χ2=4.50，P=0.042)。［结论］ careHPV检测技术初筛细胞学分流的筛查策略有助于在降低阴道镜转诊率的同时，提高宫颈病变的检出率，扩大筛查覆盖面。该策略适用于资源相对贫乏的农村地区。 |
| 英文摘要: |
| Abstract：［Purpose］ To evaluate the effect of careHPV test for cervical cancer screening in rural areas of China. ［Methods］ A total of 2270 women aged 35~64 from Xiangyuan County were enrolled for careHPV cervical cancer screening. Women with positive careHPV would be triaged by liquid-based cytology，and then those with abnormal cytology results were transferred to colposcopy and biopsy as golden standard. ［Results］ The mean age of participants was 45.7±6.8 years. The careHPV positive rate was 12.9%(292/2270). The referral rate of colposcopy was 4.8%(109/2270). The detection rates of cervical intraepithelial neoplasia grade 1(CIN1) and CIN grade 2 or worse (CIN2+) were 1.4%(31/2270) and 1.7%(38/2270)，respectively. Women with previous screening history had a lower rate of CIN2+ than those who never received screening(χ2=4.50，P=0.042). ［Conclusions］ Screening strategy of careHPV test as primary screening and cytology as triage method contributed to reducing colposcopy referral rate，improving the detection rate of cervical lesions and expanding coverage for screening. The strategy is suitable for rural areas，especially low-resource settings. |
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