| 陈祝俊,张拥黎,卢仁泉.血浆氧化型低密度脂蛋白检测在肾细胞癌诊治中的临床意义[J].中国肿瘤,2016,25(5):400-403. |
| 血浆氧化型低密度脂蛋白检测在肾细胞癌诊治中的临床意义 |
| The Clinical Value of Plasma Oxidized Low-density Lipoprotein in Renal Cell Carcinoma |
| 投稿时间：2015-08-11 |
| DOI：10.11735/j.issn.1004-0242.2016.05.A016 |
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| 中文关键词: 肾细胞癌 氧化型低密度脂蛋白 酶联免疫吸附试验 |
| 英文关键词:renal cell carcinoma oxidized low-density lipoprotein enzyme-linked immunosorbent assay |
| 基金项目:国家自然科学基金（81572552）；上海市浦江人才计划项目（14PJD010） |
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| 中文摘要: |
| 摘 要：［ 目的］ 评估血浆氧化型低密度脂蛋白（ox-LDL）检测在肾细胞癌诊疗中的临床意义。［方法］ 使用ELISA方法测定血浆ox-LDL浓度，研究对象包括84例来自复旦大学附属肿瘤医院的肾细胞癌患者以及对照人群（40名体检健康者）。［结果］ 肾细胞癌组血浆ox-LDL含量为9.28(7.93，10.93)ng/ml，显著性高于健康人群血浆ox-LDL含量7.23(6.43，8.00) ng/ml（P<0.05）。 肾细胞癌患者手术治疗后血浆ox-LDL水平较术前有所下降。 血浆ox-LDL与肿瘤大小相关；而恶性程度高的患者血浆ox-LDL较高。［结论］ 肾细胞癌患者血浆ox-LDL水平较健康者高，且ox-LDL水平与肿瘤大小和恶性程度密切相关。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the significance of Plasma Oxidized Low-density Lipoprotein (ox-LDL) in renal cell carcinoma.. ［Methods］ Plasma ox-LDL in 84 patients with renal cell carcinoma from Fudan University Shanghai Cancer Center and 40 samples from normal individuals as controls were detected by enzyme-linked immunosorbent assay. ［Results］ Plasma ox-LDL in renal cell carcinoma group［9.28(7.93，10.93)ng/ml ］was higher than that in healthy control group ［7.23(6.43，8.00) ng/ml］(P<0.05). Plasma ox-LDL level of renal cell carcinoma decreased after surgery，and it correlated with tumor volume in patients with renal cell carcinoma. The level of plasma ox-LDL was elevated with the progression of renal cell carcinoma. ［Conclusion］ Plasma ox-LDL level in patient with renal cell carcinoma was at a higher level. Furthermore，the ox-LDL level is correlated with tumor volume and tumor malignancy. |
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