| 李鸿涛,周 梅,罗 琳.环氧合酶-2和血管内皮生长因子-C在乳腺癌组织中的表达及预后生存分析[J].中国肿瘤,2016,25(4):319-323. |
| 环氧合酶-2和血管内皮生长因子-C在乳腺癌组织中的表达及预后生存分析 |
| The Expression of COX-2 and VEGF-C in Breast Cancer and Its Prognosis Significance |
| 投稿时间：2016-01-26 |
| DOI：10.11735/j.issn.1004-0242.2016.04.A015 |
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| 中文关键词: 乳腺癌 环氧合酶-2 血管内皮生长因子-C 预后 |
| 英文关键词:breast cancer cyclooxygenase 2 vascular endothelial growth factor C prognosis |
| 基金项目:新疆维吾尔自治区自然科学基金资助项目（2014211C116） |
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| 中文摘要: |
| 摘 要：［目的］ 评价乳腺癌组织中环氧合酶-2（COX-2）和血管内皮生长因子-C（VEGF-C）在基因及蛋白水平表达，分析两者与乳腺癌患者预后的关系。［方法］采用免疫组化SP法和QRT-PCR法分别检测150例乳腺癌组织中COX-2和VEGF-C在mRNA和蛋白水平表达，并采用Kaplan-meier法和COX风险回归模型分析与乳腺癌预后生存的相关危险因素。［结果］ 乳腺癌组织中COX-2和VEGF-C在mRNA和蛋白水平率均高于乳腺良性组织（58.8% vs 41.2%和58.9% vs 41.1%，P<0.01）。单因素结果显示患者COX-2表达、临床分期、腋窝淋巴结转移、Her-2表达、组织学分级与患者的预后有关；COX多因素分析显示肿瘤大小和腋窝淋巴结是影响乳腺癌患者预后的因素。［结论］ 乳腺癌患者COX-2和VEGF-C表达上调，乳腺癌组织中肿瘤大小、腋窝淋巴结转移是乳腺癌患者预后的影响因素。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of cyclooxygenase 2( COX-2) and vascular endothelial growth factor C (VEGF-C) in breast cancer，and to analyze the relationship with the prognosis of breast cancer patients. ［Methods］ The COX-2 and VEGF-C in the mRNA and protein expression levels of breast cancer tissue were detected by immunohistochemical SP method and QRT-PCR method . The prognosis factors of patients with breast cancer were analyzed with Kaplan-meier method and COX regression model .［Results］ COX-2 and VEGF-C in mRNA and protein levels in breast cancer group were significantly higher than those of benign breast tissue (58.8% vs 41.2% and 58.9% vs 41.1%，P＜0.01). Univariate factor analysis results showed that COX-2 expression，clinical stage，axillary lymph node metastasis and Her-2 expression，histological grade were correlated with prognosis of patients. Regression analysis showed that tumor size，axillary lymph node were the independent factor of prognosis of breast cancer patients. ［Conclusion］ COX-2 and VEGF-C expression can affect the prognosis of patients with breast cancer. Tumor size，axillary lymph node metastasis in breast cancer tissue are the influencing factors of the prognosis of patients with breast cancer. |
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