| 朱永云,李娟娟,赵迎春.乳腺癌CC类趋化因子5表达与上皮间质转化的相关性及其意义[J].中国肿瘤,2016,25(4):314-318. |
| 乳腺癌CC类趋化因子5表达与上皮间质转化的相关性及其意义 |
| Correlation of CC Chemokine Ligand 5 Expression with Epithelial-mesenchymal Transition in breast cancer and Its Significance |
| 投稿时间：2015-09-02 |
| DOI：10.11735/j.issn.1004-0242.2016.04.A014 |
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| 中文关键词: 乳腺癌 CCL5 MMP-9 上皮间质转化 |
| 英文关键词:breast cancer CCL5 MMP-9 epithelial-mesenchymal transition |
| 基金项目:国家自然科学基金青年基金资助项目(81302314) |
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| 中文摘要: |
| 摘 要：［目的］ 探讨乳腺癌组织CC类趋化因子5（CC chemokine ligand 5，CCL5）与上皮间质转化（epithelial-mesenchymal transition，EMT）之间的相关性，探索抑制乳腺癌浸润转移的新途径。［方法］ 应用免疫组织化学技术检测101例浸润性乳腺癌组织中CCL5、基质金属蛋白酶-9（matrix metalloproteinase 9，MMP-9）、钙黏附蛋白E（E-Cadherin）、钙黏附蛋白N（N-Cadherin）、波形蛋白（Vimentin）的表达，研究乳腺癌浸润转移关键分子CCL5、MMP-9表达与EMT之间的关联性，分析CCL5促EMT发生的可能途径。［结果］ CCL5与MMP-9的表达率和EMT的发生率分别为34.7%（35/101）、55.4%（56/101）和41.6%（42/101）。乳腺癌CCL5表达与淋巴结转移相关（P<0.05），与其他临床病理特征无关（P>0.05）。Spearman分析显示乳腺癌组织中CCL5与MMP-9表达呈正相关（r=0.276，P=0.005）。二元Logistic回归分析显示，只有MMP-9与EMT有相关性（OR=4.697，P=0.001）。［结论］ 乳腺癌组织中CCL5的表达可促进EMT的发生，其作用途径可能与上调MMP-9有关。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the correlation between the expression of CCL5 and epithelial-mesenchymal transition(EMT) in breast cancer and to explore the new approach of invasion and metastasis in breast cancer. ［Methods］ The expressions of CCL5，MMP-9，E-Cadherin，N-Cadherin and Vimentin protein were detected in the cancer cells of 101 cases with invasive breast cancer by immunohistochemistry. The relationships between the expressions of CCL5，MMP-9，and epithelial-mesenchymal transition(EMT) were analyzed，possible way of CCL5 promotes EMT was analysised. ［Results］ The expression rates of CCL5，MMP-9，and the rate of EMT were 34.7%(35/101)，55.4%(56/101)，and 41.6%(42/101)，respectively. The expression of CCL5 protein in breast cancer was correlated with lymph node metastasis(P<0.05)，but not with other clinicopathological features(P>0.05). Spearman analysis showed that the expression of CCL5 was correlated with the expression of MMP-9（r=0.276，P=0.005）. Logistic regression analysis showed that only MMP-9 induced EMT (OR=4.697，P=0.001). ［Conclusion］ The expression of CCL5 is correlated with EMT in breast cancer，maybe by up-regulation the expression of MMP-9. |
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