| 陶开义,陈奇勋,赵 强.胸腹腔镜与传统Ivor-Lewis手术对早中期食管癌患者术后生活质量的影响[J].中国肿瘤,2016,25(3):226-232. |
| 胸腹腔镜与传统Ivor-Lewis手术对早中期食管癌患者术后生活质量的影响 |
| A Comparative Study of Quality of Life After Minimally Invasive and Traditional Ivor-Lewis Oesophagectomy |
| 投稿时间：2015-10-29 |
| DOI：10.11735/j.issn.1004-0242.2016.03.A014 |
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| 中文关键词: Ivor-Lewis 胸腔镜 食管癌根治术 外科手术 生活质量 |
| 英文关键词:Ivor-Lewis thoracoscopy esophagectomy surgery quality of life |
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| 中文摘要: |
| 摘 要：［目的］ 比较胸腹腔镜与传统Ivor-Lewis手术对Ⅰ、Ⅱ期食管癌患者术后近期生活质量的影响。 ［方法］ 收集2014年2月至2014年6月浙江省肿瘤医院胸外科手术的Ⅰ、Ⅱ期食管癌患者112例，其中胸腹腔镜食管癌根治术53例，传统Ivor-Lewis术式59例。采用欧洲癌症研究与治疗组织开发的EORTC QLQ-C30 V3.0中文版及EORTC QLQ-OES18中文版评价患者术前、术后1月、6月及12月生活质量。 ［结果］ 术后1月两组总体健康状况和功能领域评分相比术前基线显著性下降（P<0.05），两组相比，总体健康状况（37.25±15.03 vs 27.34±12.38，P=0.000），躯体功能（49.93±8.04 vs 36.73±13.34，P=0.000），角色功能（38.89±10.36 vs 27.78±14.88，P=0.000），胸腹腔镜组评分优于Ivor-Lewis组。在症状领域，术后1个月两组症状（疲劳、疼痛、失眠、食欲下降、腹泻、恶心呕吐）评分比术前基线显著性升高，两组相比，疲劳症状（50.33±14.80 vs 58.87±18.30，P=0.009），疼痛症状（54.58±16.01 vs 71.64±14.42，P=0.009），返流症状（33.66±15.45 vs 46.78±15.8，P=0.000），胸腹腔镜组评分优于Ivor-Lewis组。术后6月及12月，患者总体健康状况、功能领域及症状领域较术前恢复趋势，其中疲劳、疼痛、返流症状在术后1月、6月、12月胸腹腔镜组均优于Ivor-Lewis组（P<0.05）。［结论］ 胸腹腔镜食管癌根治术患者总体术后近期生活质量优于Ivor-Lewis手术。 |
| 英文摘要: |
| Abstract：［Purpose］ To compare the short-term quality of life（QOL） between minimally invasive and traditional Ivor-Lewis oesophagectomy for stageⅠand stageⅡesophageal cancer. ［Methods］ Participants comprised 112 patients with stageⅠand stageⅡesophageal cancer from Feb.2014 to Jun.2014 in Zhejiang Cancer Hospital，59 patients underwent traditional Ivor-Lewis esophagectomy，and the other of them underwent minimally invasive oesophagectomy. The questionnaires (EORTC QLQ C-30 and EORTC QLQ OES-18) were applied to assess the quality of life of the patients before and 1，6，12 months after operation. ［Results］ The overall quality of life and functional scales were found declined in both groups 1 month after surgery(P<0.05). Patients underwent minimally invasive oesophagectomy indicated，significantly better scores in the functional scales and global quality of life 1 month after surgery，when compared with traditional Ivor-Lewis oesophagectomy，better global quality of life(37.25±15.03 vs. 27.34±12.38，P=0.000)，better physical function(49.93±8.04 vs. 36.73±13.34，P=0.000)，better role function(38.89±10.36 vs. 27.78±14.88，P=0.000) was found. And The scores of symptom scales (fatigue，pain，reflux，dyspnea，appetite loss and dry mouth) were markedly increased 1 month after surgery(P<0.05). Minimally invasive oesophagectomy showed lower scores when compared with traditional Ivor-Lewis oesophagectomy，less fatigue(50.33±14.80 vs. 58.87±18.30，P=0.009)，less pain(54.58±16.01 vs. 71.64±14.42，P=0.009)，less reflux(33.66±15.45 vs. 46.78±15.8，P=0.000)，and the advantage last for 12 months after surgery. The overall quality of life，functional scales and symptom scales were restored at 6 months or 12 months after surgery. ［Conclusions］ Minimally invasive esophagectomy provide a generally better short-term QOL for patients with esophageal cancer compared with traditional Ivor-Lewis oesophagectomy. |
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