| 张柏林,张 倩,Priya G. Sivasubramaniam.中国年轻乳腺癌发病危险因素——多中心十年回顾性研究[J].中国肿瘤,2015,24(12):1042-1047. |
| 中国年轻乳腺癌发病危险因素——多中心十年回顾性研究 |
| The Risk Factors of Breast Cancer in Young Women in China：A Multi-center Ten-years Retrospective Study |
| 投稿时间：2015-07-05 |
| DOI：10.11735/j.issn.1004-0242.2015.12.A018 |
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| 中文关键词: 乳腺癌 年轻 年龄 临床病理特征 |
| 英文关键词:breast cancer young age clinical pathological feature |
| 基金项目:中国癌症基金会辉瑞乳腺癌专项基金 |
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| 中文摘要: |
| 摘 要：［目的］ 研究年轻乳腺癌与非年轻乳腺癌患者的临床病理特征差异，探寻年轻女性罹患乳腺癌的危险因素。［方法］数据来自于一项以医院为基础的10年（1999~2008）多中心回顾性研究。对年轻组（<35岁）与非年轻组（≥35岁）患者的肿瘤大小、淋巴结转移状况和人口学信息进行统计分析。［结果］研究共纳入4211例患者。其中年轻乳腺癌患者（<35岁）295例（7.06%）。年轻组与非年轻组患者在临床病理特征方面仅有肿瘤最大径（31.91mm vs. 27.44mm，P=0.009）和淋巴结转移发生率（62.31% vs. 49.01%，P<0.001）存在统计学差异。此外，年轻乳腺癌患者的生产次数少（Ptrend<0.001）、哺乳比例低（P<0.001）。年轻患者中未婚者（P<0.001）、使用口服避孕药者（P<0.001）、饮酒者（P=0.006）均较非年轻组的比例高。年轻乳腺癌患者具有较高的脑力劳动比例（P=0.005）和较高的教育背景（Ptrend<0.001）。［结论］ 年轻乳腺癌患者在临床病理特征以及人口学信息等方面与非年轻患者存在差异。其中一些在年轻乳腺癌患者中出现频率高的变量提示了年轻患者罹患乳腺癌的危险因素。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate clinical-pathological differences between younger and old breast cancer patients and to explore the risk factors related to young patients with breast cancer. ［Methods］ This study was a hospital-based multi-center 10-years(1999~2008) retrospective study. Statistical tests were utilized to illustrate information regarding tumor size，positive lymph nodes，and demographic variables between young(<35) and old age groups(≥35) of breast cancer patients.［Results］ A total of 4211 patients were enrolled in this retrospective study by quality control methods. Among them，295(7.06%) were under 35 years old (＜35 years). The only two differences of pathological characteristics in these two groups (young patients vs. old patients) were the tumor size (31.91mm vs. 27.44mm，P=0.009) and positive rate of lymph nodes(62.31% vs. 49.01%，P<0.001). Compared to old age group，a significant greater proportion in younger women with fewer births (P trend<0.001) and fewer breast feeding(P<0.001)，greater proportion of younger women consumed alcohol (P=0.006)，unmarried(P<0.001)，had oral contraceptive history(P<0.001)，had intellectually strenuous occupations(P=0.005)，and higher levels of education (P trend<0.001). ［Conclusions］ There are significant differences in some clinicopathological and demographic features between young and older patients. Variables occurred more frequently among younger breast cancer patients indicate of risk factors for young women. |
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