| 冯婷婷,凌孙彬,方美玉.发生血栓的恶性肿瘤患者抗肿瘤治疗前的外周血液学特点分析[J].中国肿瘤,2015,24(11):966-970. |
| 发生血栓的恶性肿瘤患者抗肿瘤治疗前的外周血液学特点分析 |
| The Characteristics of Peripheral Blood Before Anti-neoplastic Therapy in Cancer Patients Complicated with Thrombosis |
| 投稿时间：2015-05-05 |
| DOI：10.11735/j.issn.1004-0242.2015.11.A016 |
|
 |
| 中文关键词: 恶性肿瘤 血栓形成 白细胞增多 大血小板值 |
| 英文关键词:neoplasms thrombosis leukocytosis large platelet count |
| 基金项目: |
|
| 摘要点击次数: 2113 |
| 全文下载次数: 806 |
| 中文摘要: |
| 摘 要：［目的］ 探究恶性肿瘤患者抗肿瘤治疗前的外周血液学特点，为肿瘤患者的血栓防治提供新线索。［方法］ 收集2003~2012年间收治的47例在抗肿瘤治疗过程中发生血栓的恶性肿瘤患者作为病例组，同期47例未出现血栓的恶性肿瘤患者为对照组的临床资料。危险因素分析采用Logistic单因素及多因素分析方法。［结果］ 抗肿瘤治疗前血常规中白细胞数、中性粒细胞绝对值、血小板绝对值、大血小板比率、大血小板值的均值，病例组较对照组显著升高（P<0.05）；血凝常规指标较对照组无显著差异（P>0.05）。Logistic分析结果示较高水平WBC及大血小板值有统计学意义（P<0.05）。而中性粒细胞绝对值、血小板绝对值、大血小板比率未显示统计学意义（P＞0.05）。 ［结论］ 抗肿瘤治疗前较高水平的白细胞、大血小板值是恶性肿瘤患者发生血栓的独立危险因素。抗肿瘤治疗前血凝常规指标对于恶性肿瘤患者发生血栓的提示作用可能较小。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the characteristics of peripheral blood before anti-neoplastic therapy，and to find new clues for prevention and treatment of thrombosis in cancer patients. ［Methods］ The 47 cases of cancer patients complicated with thrombosis treated from 2003 to 2012 were enrolled as the case group，and 47 cases of cancer patients without thrombosis as the control group. The clinical data were analyzed retrospectively，and risk factors for thrombosis were evaluated by Logistic regression. ［Results］ The patients in case group had significantly higher level in white blood count(WBC)，neutrophil(N)，platelet(PLT)，large platelet ratio (P-LCR) and large platelet count in the blood routine examination before anti-neoplastic therapy compared to the control group（P<0.05）； while there was no significant difference in activated partial prothrombin time，plasma thrombin time，plasma prothrombin international standardization，and fibrinogen between the two groups(P>0.05). Logistic regression results showed that the higher level of WBC and large platelet count had significant difference(P<0.05)，and N，PLT，P-LCR showed no statistical significance(P>0.05). ［Conclusion］ Higher levels of WBC and large platelet count before anti-neoplastic therapy are independent risk factors of complicated with thrombosis in the cancer patients. Conventional blood coagulation indexes before anti-neoplastic therapy may have limited role in the cancer patients complieated with thrombosis. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |