| 刘志军,刘红林,陈小兵.MicroRNA-326在脑胶质瘤中的表达及其临床意义[J].中国肿瘤,2015,24(11):957-960. |
| MicroRNA-326在脑胶质瘤中的表达及其临床意义 |
| The Expression of MicroRNA-326 in Gliomas and its Clinical Significance |
| 投稿时间：2015-03-04 |
| DOI：10.11735/j.issn.1004-0242.2015.11.A014 |
|
 |
| 中文关键词: 胶质瘤 microRNA-326 预后 |
| 英文关键词:glioma microRNA-326 prognosis |
| 基金项目: |
|
| 摘要点击次数: 1704 |
| 全文下载次数: 926 |
| 中文摘要: |
| 摘 要：［目的］ 探讨microRNA-326（miR-326）在脑胶质瘤中的表达及其临床意义。［方法］ 用qRT-PCR检测福尔马林固定、石蜡包埋（FFPE）的89例胶质瘤和20例正常脑组织病理标本。应用SPSS16.0分析miR-326的表达水平与临床病理学特征之间的相关性。［结果］ 脑胶质瘤（3.824±1.7011）和正常脑组织（6.135±1.2897）中miR-326的表达水平有显著性差异（P＜0.001）。miR-326的表达与肿瘤直径（P=0.029）、WHO分级（P<0.001）和KPS评分密切相关（P<0.001）；与患者的年龄（P=0.518）和性别（P=0.501）无显著性相关。MiR-326低表达与胶质瘤患者的生存率降低密切相关（P＜0.001）。胶质瘤的WHO分级增高、肿瘤直径＞3cm、KPS评分<80分及miR-326低表达均是影响胶质瘤患者预后的危险因素（P<0.05）。［结论］ miR-326在胶质瘤组织中呈低表达，其可能可成为预测胶质瘤发生发展及预后的生物标志物。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression and clinical significance of microRNA-326（miR-326） in gliomas.［Methods］ The expression of miR-326 in 89 samples with glioma and 20 samples with normal brain tissue was detected by QRT-PCR，which were treated with formalin fixed，paraffin embedding. The correlation of miR-326 expression level and clinical pathological parameters was analyzed by SPSS16.0. ［Results］ The expression of miR-326 was significantly lower in glioma tissues（3.824±1.7011）than that in normal brain tissues（6.135±1.2897）（P＜0.001）. The expression of miR-326 was significantly correlated with tumor diameter（P=0.029），WHO grade（P＜0.001）and KPS score（P＜0.001），and did not correlate with age（P=0.518）and gender（P=0.501）. The lower expression of miR-326 was significantly associated with lower survival in patients with glioma. Tumor diameter greater than 3cm，KPS score less than 80 points，advanced WHO grade and low expression of miR-326 were the independent risk factors predicting poor prognosis for glioma patients(P＜0.05). ［Conclusions］ miR-326 is down-regulated in glioma tissues. MiR-326 might be a biomarker for predicting carcinogenesis and prognosis for glioma. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |