| 闵 茜,彭 敏,宋启斌.PD-1信号通路在非小细胞肺癌中的研究进展[J].中国肿瘤,2015,24(11):928-933. |
| PD-1信号通路在非小细胞肺癌中的研究进展 |
| Research Progress of PD-1 Signal Pathway in Non-Small Cell Lung Cancer |
| 投稿时间：2015-03-27 |
| DOI：10.11735/j.issn.1004-0242.2015.11.A009 |
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| 中文关键词: PD-1信号通路 非小细胞肺癌 免疫逃逸 |
| 英文关键词:signal pathway non-small cell lung cancer immune escape |
| 基金项目:国家自然科学基金（81372407） |
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| 摘要点击次数: 2412 |
| 全文下载次数: 937 |
| 中文摘要: |
| 摘 要：近年来，对于程序性死亡因子-1（programmed death-1，PD-1）与肿瘤免疫逃逸关系的研究已越来越深入，尤其是对以PD-1信号通路为靶点的临床肿瘤治疗研究取得了令人瞩目的进步。全文对PD-1及其信号通路的理论基础、临床前证据及以PD-1通路为靶点在NSCLC中治疗研究进展进行综述，并对其应用前景进行展望。 |
| 英文摘要: |
| Abstract：Recently，the research between programmed death-1 pathway and tumor immune escape has been more and more deeply，especially for PD-1 signal pathway of clinical cancer research has made remarkable progress. This article reviewed the rationale，preclinical evidence，and clinical pharmacology of blockade of PD-1 or its ligands as therapy for NSCLC and provides an overview of agents in development. The clinical evidence to date is reviewed in this article. |
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