| 孙孝国,李 力,王金华.利用蛋白互作网络分析挖掘肝癌分子机制[J].中国肿瘤,2015,24(10):871-874. |
| 利用蛋白互作网络分析挖掘肝癌分子机制 |
| Explore the Molecular Mechanism of Liver Cancer by Protein- protein Interaction Network Analysis |
| 投稿时间：2015-04-27 |
| DOI：10.11735/j.issn.1004-0242.2015.10.A015 |
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| 中文关键词: 肝癌 基因互作网络 网络模块 分子机制 |
| 英文关键词:liver cancer protein-protein interaction network network module molecular mechanism |
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| 摘要点击次数: 2615 |
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| 中文摘要: |
| 摘 要：［目的］ 从公共数据库收集大量肝癌候选癌基因，利用蛋白互作网络分析，挖掘肝癌分子机制。［方法］ 收集Liverome数据库内肝癌候选癌基因，使用String数据构建肝癌候选癌基因的蛋白互作网络，进一步利用MCODE算法寻找定义网络中核心基因模块，然后通过功能富集分析探究模块相关的生物学功能与通路。［结果］ 共收集615个肝癌候选癌基因，蛋白互作网络分析得到一个包含486个基因以及2076个互作关系的蛋白互作网络。同时，通过MCODE算法得到6个核心基因模块，这些模块分别富集到“细胞周期”、“药物代谢”、“DNA复制与修复”等特定的生物学功能。［结论］ 这些核心基因模块以及相关功能与肝癌发生发展显著相关。 |
| 英文摘要: |
| Abstract：［Purpose］ To collect abundance candidate liver cancer genes from common database，and to explore the molecular mechanism of liver cancer by protein- protein interaction network analysis. ［Methods］ The candidate cancer genes of liver cancer from Liverome database were collected，the protein-protein interaction network(PPIN) of candidate liver cancer were constructed by String database，then the hub gene network modules from the PPIN were analyzed by using MCODE software，then functional enrichment analysis were used to find the related functions of these hub gene network modules.［Results］ A total of 615 candidate liver cancer genes were collected，and PPIN including 486 genes and 2076 interaction relationships were found by gene interaction network analysis. Moreover，6 hub gene network modules were obtained by MCODE software，these modules were enriched in certain function clusters such as cell cycle，drug metabolism，DNA replication and repair. ［Conclusion］ Hub gene modules and corresponding functions are significant related to liver cancer. |
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