| 王维民,顾贤成,陈 红.细胞核内与胞浆中p21蛋白预测胃癌术后辅助化疗疗效[J].中国肿瘤,2015,24(9):801-804. |
| 细胞核内与胞浆中p21蛋白预测胃癌术后辅助化疗疗效 |
| p21 Protein in the Nucleus and Cytoplasm in Prediciting for Efficacy of Adjuvant Chemotherapy in Gastric Cancer Patients |
| 投稿时间：2014-09-25 |
| DOI：10.11735/j.issn.1004-0242.2015.09.A019 |
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| 中文关键词: p21 胃癌 化疗 |
| 英文关键词:p21 gastric cancer chemotherapy |
| 基金项目:江苏省恶性肿瘤生物标志物与防治重点实验室开放课题（11ZLKF09）；无锡市科技局医疗与公众健康技术研发项目（CSE31N1333） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨p21蛋白与胃癌术后患者FLO方案辅助化疗疗效之间的关系。［方法］ 选取966例胃癌组织标本，采用组织芯片技术检测胃癌组织中细胞核内与胞浆中p21蛋白表达，应用Kaplan-Meier方法绘制生存曲线，Log-rank检验比较生存率。［结果］ p21在核中普遍低表达，而在浆中却呈高表达。浆p21高表达、核p21低表达者术后采取FLO方案化疗均能从总生存期（OS）中获益（P＜0.05）；相反，浆p21低表达、核p21高表达者在OS上未能获益（P＞0.05）。［结论］ p2l蛋白表达可以预测胃癌术后患者对FLO方案化疗疗效，可为胃癌术后患者的个体化治疗提供临床理论依据。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the relationship between p21 protein expression and effect of FLO adjuvant chemotherapy in gastric cancer patients. ［Methods］ The tissue microarrays with 966 cases of gastric cancer tissues were used to detect the nucleae and cytoplasmic p21 protein expression in gastric cancer，and the Kaplan-Meier curves with the Log-rank test were used to test the prognosis of gastric patients with different nucleae and cytoplasmic p21 protein expression. ［Results］ The nuclear p21 expression was generally down-regulated，while the cytoplasmic p21 was up-regulated. Moreover，the patients with low nuclear or high cytopalsmic p21 expression could benefit from the FLO chemotherapy after surgery(P<0.05). In contrast，the patients with high nuclear or low cytopalsmic p21 expression failed to benefit from FLO chemotherapy(P>0.05). ［Conclusion］ The subcellular p2l expression may be a useful biomarker to predict the FLO chemotherapy effect in gastric cancer patients，and the results will provide theoretical basis for individualized clinical treatment of gastric cancer patients. |
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