| 刘洪金,付 艳,贾森浩.贝伐珠单抗对结直肠癌细胞VEGFR1和VEGFR2表达的影响[J].中国肿瘤,2015,24(8):708-714. |
| 贝伐珠单抗对结直肠癌细胞VEGFR1和VEGFR2表达的影响 |
| The Effect of Bevacizumab on VEGFR1 and VEGFR2 Expression of Colorectal Carcinoma Cells |
| 投稿时间：2014-11-22 |
| DOI：10.11735/j.issn.1004-0242.2015.08.A016 |
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| 中文关键词: 贝伐珠单抗 结直肠癌 血管内皮生长因子1 血管内皮生长因子受体2 |
| 英文关键词:bevacizumab colorectal carcinoma VEGFR1 VEGFR2 |
| 基金项目:北京科委首都医疗特色项目（Z131107002213040）；Supported by Beijing Municipal Commission of Science and Technology（Z131107002213040） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨贝伐珠单抗对结直肠癌细胞血管内皮生长因子（VEGF）相关受体的影响。［方法］ RT-PCR、Western blotting检测不同浓度贝伐珠单抗对结直肠癌肿瘤细胞VEGF相关受体表达水平的影响。［结果］ 与对照组相比，贝伐珠单抗药物组结直肠癌细胞的VEGF表达水平均明显下降（P<0.05）；VEGFR1和VEGFR2表达水均明显上调（P<0.05）。［结论］ 贝伐珠单抗可引起了结直肠癌细胞VEGFR1和VEGFR2表达上调。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the effect of bevacizumab on vascular endothelial growth factor (VEGF) receptors on colorectal carcinoma cells. ［Methods］ The changes of VEGF receptors expression on colorectal carcinoma cell at different concentrations of bevacizumab were detected by RT-PCR and western blotting. ［Results］ Compared with the controls，the expressions of VEGF were both decreased on bevacizumab-induced colorectal carcinoma cells（P<0.05）. Besides the expressions of VEGFR1 and VEGFR2 were both up-regulated on bevacizumab-induced colorectal carcinoma cells（P<0.05）. ［Conclusions］ Bevacizumab induced the up-regulation of VEGFR1 and VEGFR2 on colorectal carcinoma cells. |
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