| 乔 丹,王智煜,文孝婷.胸腺肽α1降低老年肺癌患者化疗期间感染风险及对预后的影响[J].中国肿瘤,2015,24(8):696-701. |
| 胸腺肽α1降低老年肺癌患者化疗期间感染风险及对预后的影响 |
| Research on the Significance of Thymosin Α1 for Infection Risk and Prognosis in Elderly Lung Cancer Patients Received Chemotherapy |
| 投稿时间：2014-11-10 |
| DOI：10.11735/j.issn.1004-0242.2015.08.A014 |
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| 中文关键词: 老年 肺癌 感染 预后 胸腺肽α1 |
| 英文关键词:elderly lung cancer infection prognosis thymosin α1 |
| 基金项目:国家自然科学基金 (81201628) |
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| 摘要点击次数: 2436 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨胸腺肽α1对降低老年肺癌患者化疗期间感染风险的作用及对预后的影响。［方法］ 选取年龄>60岁、接受含铂一线化疗的老年肺癌患者198例，根据治疗方式分为实验组与对照组，实验组在化疗期间同时联合胸腺肽α1免疫支持治疗，比较两组患者化疗期间细胞免疫功能、感染率及生存率。［结果］ 治疗后实验组血清CD3+、CD4+和NK细胞明显升高，CD8+细胞明显下降，较治疗前水平及对照组均有统计学差异(P<0.05)；化疗期间实验组感染率明显低于对照组(P<0.05)。多因素分析结果显示胸腺肽α1免疫支持治疗是感染的保护性因素(OR=0.45，95%CI：0.23~0.89，P=0.021)。实验组与对照组中位生存时间分别为14.36个月和13.06个月，组间无统计学差异(P>0.05)；实验组中感染患者预后明显优于对照组(P<0.05)。 ［结论］ 胸腺肽α1能有效降低老年肺癌患者化疗期间感染率及感染相关死亡率。 |
| 英文摘要: |
| Abstract：［Purpose］ To evaluate significance of thymosin α1 (Tα1) for infection risk and prognosis in elderly lung cancer patients received chemotherapy. ［Methods］ A total of 198 cases with lung cancer over 60-years-old received platinum-based chemotherapy were classified into the control group (n=112) and the observation group with additional thymosin α1 (n=86) according to treatment schemes. Changes in cellular immunology function，infection rates and overall survival rates were compared between the two groups. ［Results］ After treatment，the levels of serum CD3+，CD4+ and NK significantly increased，CD8+ significantly decreased in the observation group comparing with the control group and the pretreatment levels(P<0.05). The infection rates of observation group were far lower than the control group(P<0.05). Multivariate Logistic regression analysis showed thymosin α1 was protective factor(OR=0.45，95%CI：0.23~0.89，P=0.021). The median survival time between observation group and control group had no statistical difference (14.36 months vs 13.06 months，P>0.05). Patients with infection in observation group had a better prognosis than those in control group(P<0.05). ［Conclusion］ Thymosin α1 can effectively decrease the infection rates and infection-related death rates of elderly lung cancer patients who received platinum-based chemotherapy. |
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