| 叶因涛,孙 蓓,王 冬.氨基酸载体抗肿瘤活性研究进展[J].中国肿瘤,2015,24(8):666-670. |
| 氨基酸载体抗肿瘤活性研究进展 |
| Research Progress in Antitumor Activity of Amino Acid Carrier |
| 投稿时间：2015-01-24 |
| DOI：10.11735/j.issn.1004-0242.2015.08.A009 |
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| 中文关键词: 氨基酸 载体 抗肿瘤活性 |
| 英文关键词:amino acids carrier anti-tumor activity |
| 基金项目:天津市应用基础与前沿技术研究计划一般项目（14JCYBJC28600）；天津医科大学科学基金青年项目(2014KYQ06) |
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| 中文摘要: |
| 摘 要：氨基酸是构成生物体蛋白质并同生命活动有关的最基本物质，氨基酸载体具有良好的生物相容性和亲和性，将氨基酸引入抗肿瘤药物分子中，可提高对肿瘤细胞的选择性，增加药物的溶解性，降低对正常细胞的毒性。随着对其构效关系及作用机制的不断研究，氨基酸类衍生物在抗肿瘤药物中的应用前景广阔。全文总结氨基酸类化合物衍生化后抗肿瘤作用的研究进展及应用，为抗肿瘤药物的研发提供参考。 |
| 英文摘要: |
| Abstract：Amino acids were the most basic substances，which were related with life activities and constituted the organism Protein. Amino acid carriers had good biocompatibility and affinity.The amino acid molecule was introduced into anticancer drugs，which could increase the selectivity of tumor cells，inhibit the proliferation of tumor cells，increase drugs’ solubility，enhance anti-tumor activity and decrease the toxicity on normal cells. Amino acid derivatives had been widely used in anticancer drugs. The application of amino acid derivatives were more prospective in anti-tumor drugs with ongoing to study the structure-activity relationship and mechanism. The articles related to the present and future application of anti-tumor effects of amino acid derivative compounds were analyzed in this article，in order to lay the foundation for anti-tumor drugs’ developing. |
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